DYNLL1 - Gene info - The Human Protein Atlas

DYNLL1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	DYNLL1 (HGNC Symbol)
Synonyms	DLC1, DLC8, DNCL1, hdlc1, LC8, PIN
Description	Dynein, light chain, LC8-type 1 (HGNC Symbol)
Entrez gene summary	Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	120907653 - 120936296
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088986 (version 75.37)
Entrez gene	8655
UniProt	P63167 (UniProt - Evidence at protein level)
neXtProt	NX_P63167
Antibodypedia	DYNLL1 antibodies

PROTEIN VIEW

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DYNLL1-001		DYNLL1-002		DYNLL1-003		DYNLL1-004		DYNLL1-005		DYNLL1-006		DYNLL1-007		DYNLL1-008		DYNLL1-009		DYNLL1-010

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
DYNLL1-001	ENSP00000242577 ENST00000242577	P63167 Show all » « Hide P63167 [Direct mapping] Dynein light chain 1, cytoplasmic Q6FGH9 [Target identity:100%; Query identity:100%] DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA F8VXI7 [Target identity:47%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005868 [cytoplasmic dynein complex] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007017 [microtubule-based process] GO:0007292 [female gamete generation] GO:0008022 [protein C-terminus binding] GO:0008180 [COP9 signalosome] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030036 [actin cytoskeleton organization] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042326 [negative regulation of phosphorylation] GO:0042803 [protein homodimerization activity] GO:0072686 [mitotic spindle] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]	89	10.4	No	0
DYNLL1-002	ENSP00000447494 ENST00000550845	F8VRV5 Show all » « Hide F8VRV5 [Target identity:100%; Query identity:100%] Dynein light chain 1, cytoplasmic F8VXI7 [Target identity:62%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005829 [cytosol] GO:0005875 [microtubule associated complex] GO:0007017 [microtubule-based process] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042803 [protein homodimerization activity]	67	7.2	No	0
DYNLL1-003	ENSP00000376296 ENST00000392508	P63167 Show all » « Hide P63167 [Direct mapping] Dynein light chain 1, cytoplasmic Q6FGH9 [Target identity:100%; Query identity:100%] DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA F8VXI7 [Target identity:47%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005868 [cytoplasmic dynein complex] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007017 [microtubule-based process] GO:0007292 [female gamete generation] GO:0008022 [protein C-terminus binding] GO:0008180 [COP9 signalosome] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030036 [actin cytoskeleton organization] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042326 [negative regulation of phosphorylation] GO:0042803 [protein homodimerization activity] GO:0072686 [mitotic spindle] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]	89	10.4	No	0
DYNLL1-004	ENSP00000447907 ENST00000548342	P63167 Show all » « Hide P63167 [Direct mapping] Dynein light chain 1, cytoplasmic Q6FGH9 [Target identity:100%; Query identity:100%] DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA F8VXI7 [Target identity:47%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005868 [cytoplasmic dynein complex] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007017 [microtubule-based process] GO:0007292 [female gamete generation] GO:0008022 [protein C-terminus binding] GO:0008180 [COP9 signalosome] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030036 [actin cytoskeleton organization] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042326 [negative regulation of phosphorylation] GO:0042803 [protein homodimerization activity] GO:0072686 [mitotic spindle] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]	89	10.4	No	0
DYNLL1-005	ENSP00000448834 ENST00000549649	F8VXI7 Show all » « Hide F8VXI7 [Target identity:100%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005829 [cytosol] GO:0005875 [microtubule associated complex] GO:0007017 [microtubule-based process] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042803 [protein homodimerization activity]	42	4.8	No	0
DYNLL1-006	ENSP00000376297 ENST00000392509	P63167 Show all » « Hide P63167 [Direct mapping] Dynein light chain 1, cytoplasmic Q6FGH9 [Target identity:100%; Query identity:100%] DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA F8VXI7 [Target identity:47%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Cytoskeleton related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005868 [cytoplasmic dynein complex] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007017 [microtubule-based process] GO:0007292 [female gamete generation] GO:0008022 [protein C-terminus binding] GO:0008180 [COP9 signalosome] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030036 [actin cytoskeleton organization] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042326 [negative regulation of phosphorylation] GO:0042803 [protein homodimerization activity] GO:0072686 [mitotic spindle] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]	89	10.4	No	0
DYNLL1-007	ENSP00000448608 ENST00000548214	F8VRV5 Show all » « Hide F8VRV5 [Target identity:100%; Query identity:100%] Dynein light chain 1, cytoplasmic F8VXI7 [Target identity:62%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005829 [cytosol] GO:0005875 [microtubule associated complex] GO:0007017 [microtubule-based process] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042803 [protein homodimerization activity]	67	7.2	No	0
DYNLL1-008	ENSP00000446614 ENST00000549989	P63167 Show all » « Hide P63167 [Direct mapping] Dynein light chain 1, cytoplasmic Q6FGH9 [Target identity:100%; Query identity:100%] DNCL1 protein; Dynein, light chain, LC8-type 1; Dynein, light chain, LC8-type 1, isoform CRA_a; cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA F8VXI7 [Target identity:47%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005868 [cytoplasmic dynein complex] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007017 [microtubule-based process] GO:0007292 [female gamete generation] GO:0008022 [protein C-terminus binding] GO:0008180 [COP9 signalosome] GO:0009653 [anatomical structure morphogenesis] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030036 [actin cytoskeleton organization] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042326 [negative regulation of phosphorylation] GO:0042803 [protein homodimerization activity] GO:0072686 [mitotic spindle] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]	89	10.4	No	0
DYNLL1-009	ENSP00000449088 ENST00000552870	F8VXL2 Show all » « Hide F8VXL2 [Target identity:100%; Query identity:100%] Dynein light chain 1, cytoplasmic F8VXI7 [Target identity:89%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005829 [cytosol] GO:0005875 [microtubule associated complex] GO:0007017 [microtubule-based process] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042803 [protein homodimerization activity]	47	5.4	No	0
DYNLL1-010	ENSP00000446596 ENST00000550178	F8VRV5 Show all » « Hide F8VRV5 [Target identity:100%; Query identity:100%] Dynein light chain 1, cytoplasmic F8VXI7 [Target identity:62%; Query identity:100%] Dynein light chain 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005829 [cytosol] GO:0005875 [microtubule associated complex] GO:0007017 [microtubule-based process] GO:0008022 [protein C-terminus binding] GO:0016020 [membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0042803 [protein homodimerization activity]	67	7.2	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.