PHGDH

GENE INFORMATION

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Gene name

PHGDH (HGNC Symbol)

Synonyms

PDG, PGDH, SERA

Description

Phosphoglycerate dehydrogenase (HGNC Symbol)

Entrez gene summary

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

p12

Chromosome location (bp)

120202421 - 120286838

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000092621 (version 75.37)

Entrez gene

26227

UniProt

O43175 (UniProt - Evidence at protein level)

neXtProt

NX_O43175

Antibodypedia

PHGDH antibodies
 

PROTEIN VIEW

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PHGDH-001
 
PHGDH-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHGDH-001 ENSP00000358417
ENST00000369409
O43175
Show all »
Show » Show » 533 56.6 No 0
PHGDH-002 ENSP00000358415
ENST00000369407
Q5SZU1
Show all »
Show » Show » 499 53.1 No 0