TPSD1

GENE INFORMATION

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Gene name

TPSD1

Synonyms

Description

Tryptase delta 1 (HGNC Symbol)

Entrez gene summary

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

1306060 - 1308532

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095917 (version 75.37)

Entrez gene

23430

UniProt

Q9BZJ3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZJ3

Antibodypedia

TPSD1 antibodies
 

PROTEIN VIEW

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TPSD1-001
 
TPSD1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPSD1-001 ENSP00000211076
ENST00000211076
Q9BZJ3
Show all »
Show » Show » 242 26.6 Yes 0
TPSD1-002 ENSP00000380668
ENST00000397534
Q9BZJ3
Show all »
Show » Show » 235 25.8 Yes 0