HIRA

GENE INFORMATION

? »

Gene name

HIRA (HGNC Symbol)

Synonyms

DGCR1, TUP1, TUPLE1

Description

Histone cell cycle regulator (HGNC Symbol)

Entrez gene summary

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19318221 - 19435224

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100084 (version 75.37)

Entrez gene

7290

UniProt

P54198 (UniProt - Evidence at protein level)

neXtProt

NX_P54198

Antibodypedia

HIRA antibodies
 

PROTEIN VIEW

? »
 
 
 
HIRA-001
 
HIRA-002
 
HIRA-004
 
HIRA-201
 
HIRA-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIRA-001 ENSP00000263208
ENST00000263208
P54198
Show all »
Show » Show » 1017 111.8 No 0
HIRA-002 ENSP00000345350
ENST00000340170
P54198
Show all »
Show » Show » 810 89.3 No 0
HIRA-004 ENSP00000404792
ENST00000452818
Show » 53 6.1 No 0
HIRA-201 ENSP00000446073
ENST00000541063
F5H4M2
Show all »
Show » Show » 973 107 No 0
HIRA-202 ENSP00000441870
ENST00000546308
L7N2F8
Show all »
Show » Show » 806 88.1 No 0