TBL1X - Gene info - The Human Protein Atlas

TBL1X

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	TBL1X (HGNC Symbol)
Synonyms	EBI, TBL1
Description	Transducin (beta)-like 1X-linked (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	9431335 - 9687780
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101849 (version 75.37)
Entrez gene	6907
UniProt	O60907 (UniProt - Evidence at protein level)
neXtProt	NX_O60907
Antibodypedia	TBL1X antibodies

PROTEIN VIEW

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TBL1X-001		TBL1X-002		TBL1X-003		TBL1X-004		TBL1X-005		TBL1X-006		TBL1X-201		TBL1X-202		TBL1X-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
TBL1X-001	ENSP00000397878 ENST00000452824	C9J5F9 Show all » « Hide C9J5F9 [Target identity:100%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JP56 [Target identity:73%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		80	8.8	No	0
TBL1X-002	ENSP00000370348 ENST00000380961	O60907 Show all » « Hide O60907 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X C9JYQ8 [Target identity:14%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JCW3 [Target identity:8%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005876 [spindle microtubule] GO:0006351 [transcription, DNA-templated] GO:0006508 [proteolysis] GO:0007219 [Notch signaling pathway] GO:0007605 [sensory perception of sound] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0017053 [transcriptional repressor complex] GO:0019904 [protein domain specific binding] GO:0042393 [histone binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060070 [canonical Wnt signaling pathway]	526	57	No	0
TBL1X-003	ENSP00000217964 ENST00000217964	O60907 Show all » « Hide O60907 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X C9J5F9 [Target identity:13%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JYQ8 [Target identity:12%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JP56 [Target identity:10%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JCW3 [Target identity:7%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005876 [spindle microtubule] GO:0006351 [transcription, DNA-templated] GO:0006508 [proteolysis] GO:0007219 [Notch signaling pathway] GO:0007605 [sensory perception of sound] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0017053 [transcriptional repressor complex] GO:0019904 [protein domain specific binding] GO:0042393 [histone binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060070 [canonical Wnt signaling pathway]	577	62.5	No	0
TBL1X-004	ENSP00000402923 ENST00000441088	C9JP56 Show all » « Hide C9JP56 [Target identity:100%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		59	6.3	No	0
TBL1X-005	ENSP00000407069 ENST00000415293	C9JYQ8 Show all » « Hide C9JYQ8 [Target identity:100%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JCW3 [Target identity:60%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005667 [transcription factor complex] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	75	8.2	No	0
TBL1X-006	ENSP00000415508 ENST00000422314	C9JCW3 Show all » « Hide C9JCW3 [Target identity:100%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005667 [transcription factor complex] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	45	5	No	0
TBL1X-201	ENSP00000385988 ENST00000407597	O60907 Show all » « Hide O60907 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X C9J5F9 [Target identity:13%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JYQ8 [Target identity:12%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JP56 [Target identity:10%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JCW3 [Target identity:7%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005876 [spindle microtubule] GO:0006351 [transcription, DNA-templated] GO:0006508 [proteolysis] GO:0007219 [Notch signaling pathway] GO:0007605 [sensory perception of sound] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0017053 [transcriptional repressor complex] GO:0019904 [protein domain specific binding] GO:0042393 [histone binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060070 [canonical Wnt signaling pathway]	577	62.5	No	0
TBL1X-202	ENSP00000394097 ENST00000424279	O60907 Show all » « Hide O60907 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X C9JYQ8 [Target identity:14%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JCW3 [Target identity:8%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005876 [spindle microtubule] GO:0006351 [transcription, DNA-templated] GO:0006508 [proteolysis] GO:0007219 [Notch signaling pathway] GO:0007605 [sensory perception of sound] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0017053 [transcriptional repressor complex] GO:0019904 [protein domain specific binding] GO:0042393 [histone binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060070 [canonical Wnt signaling pathway]	526	57	No	0
TBL1X-203	ENSP00000445317 ENST00000536365	O60907 Show all » « Hide O60907 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X C9JYQ8 [Target identity:14%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X C9JCW3 [Target identity:8%; Query identity:100%] F-box-like/WD repeat-containing protein TBL1X	Show » « Hide Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005876 [spindle microtubule] GO:0006351 [transcription, DNA-templated] GO:0006508 [proteolysis] GO:0007219 [Notch signaling pathway] GO:0007605 [sensory perception of sound] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0017053 [transcriptional repressor complex] GO:0019904 [protein domain specific binding] GO:0042393 [histone binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043627 [response to estrogen stimulus] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045444 [fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060070 [canonical Wnt signaling pathway]	526	57	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.