CLEC4M

GENE INFORMATION

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Gene name

CLEC4M (HGNC Symbol)

Synonyms

CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, LSIGN

Description

C-type lectin domain family 4, member M (HGNC Symbol)

Entrez gene summary

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

7828035 - 7834491

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104938 (version 75.37)

Entrez gene

10332

UniProt

Q9H2X3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H2X3

Antibodypedia

CLEC4M antibodies
 

PROTEIN VIEW

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CLEC4M-001
 
CLEC4M-003
 
CLEC4M-004
 
CLEC4M-005
 
CLEC4M-006
 
CLEC4M-008
 
CLEC4M-201
 
CLEC4M-202
 
CLEC4M-203
 
CLEC4M-204
 
CLEC4M-205
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLEC4M-001 ENSP00000316228
ENST00000327325
Q9H2X3
Show all »
Show » Show » 399 45.3 No 1
CLEC4M-003 ENSP00000470137
ENST00000596707
M0QYX2
Show all »
Show » Show » 332 38 No 0
CLEC4M-004 ENSP00000471125
ENST00000596363
Q9H2X3
Show all »
Show » Show » 296 33.5 No 0
CLEC4M-005 ENSP00000471132
ENST00000597522
Q9H2X3
Show all »
Show » Show » 232 26.3 No 1
CLEC4M-006 ENSP00000470132
ENST00000595496
Q9H2X3
Show all »
Show » Show » 263 30.1 No 0
CLEC4M-008 ENSP00000470286
ENST00000595751
M0QZ42
Show all »
Show » 282 32.2 No 0
CLEC4M-201 ENSP00000248228
ENST00000248228
H7BXE2
Show all »
Show » Show » 377 42.8 No 1
CLEC4M-202 ENSP00000335228
ENST00000334806
H7BXU4
Show all »
Show » Show » 348 39.5 No 0
CLEC4M-203 ENSP00000349924
ENST00000357361
Q9H2X3
Show all »
Show » Show » 324 36.8 No 1
CLEC4M-204 ENSP00000351954
ENST00000359059
Q9H2X3
Show all »
Show » Show » 332 38 No 0
CLEC4M-205 ENSP00000377680
ENST00000394122
E7ENS9
Show all »
Show » Show » 387 44.1 No 1