PON2

GENE INFORMATION

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Gene name

PON2

Synonyms

Description

Paraoxonase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q21.3

Chromosome location (bp)

95034175 - 95064510

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105854 (version 75.37)

Entrez gene

5445

UniProt

Q15165 (UniProt - Evidence at protein level)

neXtProt

NX_Q15165

Antibodypedia

PON2 antibodies
 

PROTEIN VIEW

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PON2-001
 
PON2-002
 
PON2-003
 
PON2-004
 
PON2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PON2-001 ENSP00000404622
ENST00000433091
J3QT77
Show all »
Show » Show » 342 38 Yes 0
PON2-002 ENSP00000222572
ENST00000222572
Q15165
Show all »
Show » Show » 354 39.4 Yes 0
PON2-003 ENSP00000414515
ENST00000455123
G3XAK4
Show all »
Show » Show » 219 24.6 Yes 0
PON2-004 ENSP00000405211
ENST00000446142
Q15165
Show all »
Show » Show » 50 5.5 No 0
PON2-201 ENSP00000440282
ENST00000536183
G3V1K3
Show all »
Show » Show » 375 41.5 No 0