PLOD3 - Gene info - The Human Protein Atlas

PLOD3

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PLOD3 (HGNC Symbol)
Synonyms	LH3
Description	Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100849258 - 100861701
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106397 (version 75.37)
Entrez gene	8985
UniProt	O60568 (UniProt - Evidence at protein level)
neXtProt	NX_O60568
Antibodypedia	PLOD3 antibodies

PROTEIN VIEW

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PLOD3-001		PLOD3-005		PLOD3-007		PLOD3-008		PLOD3-009		PLOD3-013		PLOD3-017

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PLOD3-001	ENSP00000223127 ENST00000223127	O60568 Show all » « Hide O60568 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 C9JIX5 [Target identity:10%; Query identity:100%] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Show » « Hide Oxidoreductases Enzymes ENZYME proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001701 [in utero embryonic development] GO:0001886 [endothelial cell morphogenesis] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006464 [cellular protein modification process] GO:0008104 [protein localization] GO:0008475 [procollagen-lysine 5-dioxygenase activity] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0021915 [neural tube development] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030867 [rough endoplasmic reticulum membrane] GO:0031418 [L-ascorbic acid binding] GO:0032870 [cellular response to hormone stimulus] GO:0033823 [procollagen glucosyltransferase activity] GO:0042311 [vasodilation] GO:0048730 [epidermis morphogenesis] GO:0050211 [procollagen galactosyltransferase activity] GO:0055114 [oxidation-reduction process] GO:0060425 [lung morphogenesis] GO:0070831 [basement membrane assembly]	738	84.8	Yes	0
PLOD3-005	ENSP00000416070 ENST00000456079	C9JIX5 Show all » « Hide C9JIX5 [Target identity:100%; Query identity:100%] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001701 [in utero embryonic development] GO:0001886 [endothelial cell morphogenesis] GO:0008104 [protein localization] GO:0008475 [procollagen-lysine 5-dioxygenase activity] GO:0021915 [neural tube development] GO:0030199 [collagen fibril organization] GO:0032870 [cellular response to hormone stimulus] GO:0033823 [procollagen glucosyltransferase activity] GO:0042311 [vasodilation] GO:0048730 [epidermis morphogenesis] GO:0060425 [lung morphogenesis] GO:0070831 [basement membrane assembly]	76	8.4	Yes	0
PLOD3-007	ENSP00000407551 ENST00000414785	C9JU11 Show all » « Hide C9JU11 [Target identity:100%; Query identity:100%] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Show » « Hide SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		171	19.1	No	0
PLOD3-008	ENSP00000404799 ENST00000424135	H7C2A8 Show all » « Hide H7C2A8 [Target identity:100%; Query identity:100%] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		125	13.9	No	0
PLOD3-009	ENSP00000407908 ENST00000421736		Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		270	31.1	No	0
PLOD3-013	ENSP00000394045 ENST00000440925		Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		66	7.6	No	0
PLOD3-017	ENSP00000407555 ENST00000454310		Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005506 [iron ion binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0031418 [L-ascorbic acid binding] GO:0055114 [oxidation-reduction process]	264	30.7	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.