PTGDS

GENE INFORMATION

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Gene name

PTGDS (HGNC Symbol)

Synonyms

L-PGDS, PGDS

Description

Prostaglandin D2 synthase 21kDa (brain) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.3

Chromosome location (bp)

139871956 - 139879887

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107317 (version 75.37)

Entrez gene

5730

UniProt

P41222 (UniProt - Evidence at protein level)

neXtProt

NX_P41222

Antibodypedia

PTGDS antibodies
 

PROTEIN VIEW

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PTGDS-001
 
PTGDS-002
 
PTGDS-003
 
PTGDS-004
 
PTGDS-005
 
PTGDS-008
 
PTGDS-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGDS-001 ENSP00000360687
ENST00000371625
P41222
Show all »
Show » Show » 190 21 Yes 0
PTGDS-002 ENSP00000435033
ENST00000471521
P41222
Show all »
Show » Show » 190 21 Yes 0
PTGDS-003 ENSP00000392633
ENST00000457950
Q5SQ11
Show all »
Show » Show » 195 21.1 Yes 0
PTGDS-004 ENSP00000360685
ENST00000371623
Q5SQ12
Show all »
Show » Show » 160 16.9 Yes 0
PTGDS-005 ENSP00000397468
ENST00000446677
Show » 213 22.8 No 0
PTGDS-008 ENSP00000392692
ENST00000444903
Show » 62 6.4 No 0
PTGDS-201 ENSP00000224167
ENST00000224167
F8W7I2
Show all »
Show » Show » 224 24.4 Yes 0