DKK1

GENE INFORMATION

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Gene name

DKK1 (HGNC Symbol)

Synonyms

DKK-1, SK

Description

Dickkopf WNT signaling pathway inhibitor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q21.1

Chromosome location (bp)

54074056 - 54077802

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107984 (version 75.37)

Entrez gene

22943

UniProt

O94907 (UniProt - Evidence at protein level)

neXtProt

NX_O94907

Antibodypedia

DKK1 antibodies
 

PROTEIN VIEW

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DKK1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DKK1-003 ENSP00000363081
ENST00000373970
O94907
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