HNF1B

GENE INFORMATION

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Gene name

HNF1B (HGNC Symbol)

Synonyms

HNF1beta, LFB3, MODY5, TCF2, VHNF1

Description

HNF1 homeobox B (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

36046435 - 36105237

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108753 (version 75.37)

Entrez gene

6928

UniProt

P35680 (UniProt - Evidence at protein level)

neXtProt

NX_P35680

Antibodypedia

HNF1B antibodies
 

PROTEIN VIEW

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HNF1B-001
 
HNF1B-003
 
HNF1B-004
 
HNF1B-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HNF1B-001 ENSP00000225893
ENST00000225893
P35680
Show all »
Show » Show » 557 61.3 No 0
HNF1B-003 ENSP00000452674
ENST00000561193
P35680
Show all »
Show » Show » 531 58.4 No 0
HNF1B-004 ENSP00000412212
ENST00000427275
P35680
Show all »
Show » Show » 457 50.3 No 0
HNF1B-005 ENSP00000453099
ENST00000560016
H0YL84
Show all »
Show » Show » 548 60.2 No 0