TRIM2

GENE INFORMATION

? »

Gene name

TRIM2 (HGNC Symbol)

Synonyms

KIAA0517, RNF86

Description

Tripartite motif containing 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

154073494 - 154260472

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109654 (version 75.37)

Entrez gene

23321

UniProt

Q9C040 (UniProt - Evidence at protein level)

neXtProt

NX_Q9C040

Antibodypedia

TRIM2 antibodies
 

PROTEIN VIEW

? »
 
 
 
TRIM2-001
 
TRIM2-004
 
TRIM2-006
 
TRIM2-010
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRIM2-001 ENSP00000339659
ENST00000338700
Q9C040
Show all »
Show » Show » 771 84.5 No 0
TRIM2-004 ENSP00000415812
ENST00000437508
Q9C040
Show all »
Show » Show » 744 81.5 No 0
TRIM2-006 ENSP00000400879
ENST00000441616
C9JVI3
Show all »
Show » Show » 138 15.2 No 0
TRIM2-010 ENSP00000400375
ENST00000433687
C9J084
Show all »
Show » Show » 110 12.1 No 0