CALCA - Gene info - The Human Protein Atlas

Gene name

CALCA (HGNC Symbol)

Synonyms

CALC1

Description

Calcitonin-related polypeptide alpha (HGNC Symbol)

Entrez gene summary

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Chromosome

Cytoband

p15.2

Chromosome location (bp)

14988214 - 14993900

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110680 (version 75.37)

Entrez gene

796

UniProt

P01258 (UniProt - Evidence at protein level), P06881 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CALCA-001

ENSP00000331746
ENST00000331587

P01258
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P01258 [Direct mapping]
Calcitonin Calcitonin Katacalcin

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)

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GO:0001984 [vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002548 [monocyte chemotaxis]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007631 [feeding behavior]
GO:0008016 [regulation of heart contraction]
GO:0009408 [response to heat]
GO:0030279 [negative regulation of ossification]
GO:0030424 [axon]
GO:0031645 [negative regulation of neurological system process]
GO:0031716 [calcitonin receptor binding]
GO:0032147 [activation of protein kinase activity]
GO:0042311 [vasodilation]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045776 [negative regulation of blood pressure]
GO:0045778 [positive regulation of ossification]
GO:0045779 [negative regulation of bone resorption]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045986 [negative regulation of smooth muscle contraction]
GO:0048265 [response to pain]
GO:0050727 [regulation of inflammatory response]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]

141

15.5

Yes

CALCA-002

ENSP00000420618
ENST00000469608

P01258
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P01258 [Direct mapping]
Calcitonin Calcitonin Katacalcin

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GO:0001984 [vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002548 [monocyte chemotaxis]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007631 [feeding behavior]
GO:0009408 [response to heat]
GO:0030279 [negative regulation of ossification]
GO:0031645 [negative regulation of neurological system process]
GO:0031716 [calcitonin receptor binding]
GO:0032147 [activation of protein kinase activity]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045778 [positive regulation of ossification]
GO:0045779 [negative regulation of bone resorption]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045986 [negative regulation of smooth muscle contraction]
GO:0048265 [response to pain]
GO:0050727 [regulation of inflammatory response]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]

141

15.5

Yes

CALCA-003

ENSP00000379657
ENST00000396372

P01258
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P01258 [Direct mapping]
Calcitonin Calcitonin Katacalcin

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GO:0001984 [vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002548 [monocyte chemotaxis]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007631 [feeding behavior]
GO:0009408 [response to heat]
GO:0030279 [negative regulation of ossification]
GO:0031645 [negative regulation of neurological system process]
GO:0031716 [calcitonin receptor binding]
GO:0032147 [activation of protein kinase activity]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045778 [positive regulation of ossification]
GO:0045779 [negative regulation of bone resorption]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045986 [negative regulation of smooth muscle contraction]
GO:0048265 [response to pain]
GO:0050727 [regulation of inflammatory response]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]

141

15.5

Yes

CALCA-004

ENSP00000417833
ENST00000486207

P06881
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P06881 [Direct mapping]
Calcitonin gene-related peptide 1

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Transporters
   Transporter channels and pores
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

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GO:0001935 [endothelial cell proliferation]
GO:0001944 [vasculature development]
GO:0001976 [neurological system process involved in regulation of systemic arterial blood pressure]
GO:0002031 [G-protein coupled receptor internalization]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0008217 [regulation of blood pressure]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031623 [receptor internalization]
GO:0032403 [protein complex binding]
GO:0032730 [positive regulation of interleukin-1 alpha production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0043542 [endothelial cell migration]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045776 [negative regulation of blood pressure]
GO:0045779 [negative regulation of bone resorption]
GO:0045909 [positive regulation of vasodilation]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]

128

13.9

Yes

CALCA-201

ENSP00000352663
ENST00000359642

P01258
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P01258 [Direct mapping]
Calcitonin Calcitonin Katacalcin

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GO:0001984 [vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure]
GO:0002027 [regulation of heart rate]
GO:0002548 [monocyte chemotaxis]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007631 [feeding behavior]
GO:0009408 [response to heat]
GO:0030279 [negative regulation of ossification]
GO:0031645 [negative regulation of neurological system process]
GO:0031716 [calcitonin receptor binding]
GO:0032147 [activation of protein kinase activity]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045778 [positive regulation of ossification]
GO:0045779 [negative regulation of bone resorption]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045986 [negative regulation of smooth muscle contraction]
GO:0048265 [response to pain]
GO:0050727 [regulation of inflammatory response]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]

141

15.5

Yes

CALCA-202

ENSP00000354286
ENST00000361010

P06881
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P06881 [Direct mapping]
Calcitonin gene-related peptide 1

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128

13.9

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.