LAMA4

GENE INFORMATION

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Gene name

LAMA4 (HGNC Symbol)

Synonyms

LAMA3

Description

Laminin, alpha 4 (HGNC Symbol)

Entrez gene summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

Chromosome

6

Cytoband

q21

Chromosome location (bp)

112429963 - 112576141

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112769 (version 75.37)

Entrez gene

3910

UniProt

Q16363 (UniProt - Evidence at protein level)

neXtProt

NX_Q16363

Antibodypedia

LAMA4 antibodies
 

PROTEIN VIEW

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 « 
 
LAMA4-001
 
LAMA4-002
 
LAMA4-003
 
LAMA4-005
 
LAMA4-006
 
LAMA4-007
 
LAMA4-008
 
LAMA4-009
 
LAMA4-010
 
LAMA4-011
 
LAMA4-012
 
LAMA4-014
 
LAMA4-015
 
LAMA4-016
 
LAMA4-019
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LAMA4-001 ENSP00000230538
ENST00000230538
Q16363
Show all »
Show » Show » 1823 202.5 Yes 0
LAMA4-002 ENSP00000412136
ENST00000431543
Q6LET9
Show all »
Show » Show » 129 13.4 Yes 0
LAMA4-003 ENSP00000357629
ENST00000368640
Show » Show » 178 19.5 No 0
LAMA4-005 ENSP00000357627
ENST00000368638
Q16363
Show all »
Show » Show » 120 12.8 Yes 0
LAMA4-006 ENSP00000408604
ENST00000455073
Q16363
Show all »
Show » Show » 120 12.8 Yes 0
LAMA4-007 ENSP00000427865
ENST00000521732
Show » Show » 187 20.4 No 0
LAMA4-008 ENSP00000429488
ENST00000522006
Q16363
Show all »
Show » Show » 1816 201.8 Yes 0
LAMA4-009 ENSP00000374114
ENST00000389463
Q16363
Show all »
Show » Show » 1816 201.8 Yes 0
LAMA4-010 ENSP00000398226
ENST00000453937
Q16363
Show all »
Show » Show » 120 12.8 Yes 0
LAMA4-011 ENSP00000430336
ENST00000521398
E5RFQ2
Show all »
Show » Show » 331 35.4 Yes 0
LAMA4-012 ENSP00000416470
ENST00000424408
Q16363
Show all »
Show » Show » 1816 201.8 Yes 0
LAMA4-014 ENSP00000430415
ENST00000521690
E5RK79
Show all »
Show » Show » 81 8.6 Yes 0
LAMA4-015 ENSP00000428583
ENST00000519932
E5RHF3
Show all »
Show » Show » 107 11.3 Yes 0
LAMA4-016 ENSP00000243219
ENST00000243219
E5RFD7
Show all »
Show » Show » 88 9.3 Yes 0
LAMA4-019 ENSP00000427837
ENST00000523765
Show » 188 20.7 No 0