SMAD5 - Gene info - The Human Protein Atlas

Gene name

SMAD5 (HGNC Symbol)

Synonyms

Dwfc, JV5-1, MADH5

Description

SMAD family member 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

Cytoband

q31.1

Chromosome location (bp)

135468534 - 135524435

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113658 (version 75.37)

Entrez gene

4090

UniProt

Q99717 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMAD5-002

ENSP00000425749
ENST00000507118

D6RIZ9
Show all » « Hide

D6RIZ9 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog 5
D6R9D4 [Target identity:62%; Query identity:100%]
Mothers against decapentaplegic homolog 5

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

128

14.7

SMAD5-003

ENSP00000424279
ENST00000511116

D6RBB4
Show all » « Hide

D6RBB4 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog 5
D6RIZ9 [Target identity:95%; Query identity:100%]
Mothers against decapentaplegic homolog 5
D6R9D4 [Target identity:59%; Query identity:100%]
Mothers against decapentaplegic homolog 5

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

134

15.4

SMAD5-004

ENSP00000426696
ENST00000509297

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

0.1

SMAD5-005

ENSP00000427330
ENST00000515005

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

0.1

SMAD5-008

ENSP00000422954
ENST00000506223

D6R9D4
Show all » « Hide

D6R9D4 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog 5

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

8.8

SMAD5-010

ENSP00000427474
ENST00000507637

Show » « Hide

SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]

174

19.1

SMAD5-012

ENSP00000427650
ENST00000513418

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]

6.7

SMAD5-201

ENSP00000441954
ENST00000545279

Q99717
Show all » « Hide

Q99717 [Target identity:100%; Query identity:99%]
Mothers against decapentaplegic homolog 5
F5GWU7 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog 5
Q68DB7 [Target identity:100%; Query identity:99%]
Putative uncharacterized protein DKFZp781C1895; Putative uncharacterized protein DKFZp781O1323; SMAD, mothers against DPP homolog 5 (Drosophila), isoform CRA_b; cDNA, FLJ93932, Homo sapiens MAD, mothers against decapentaplegic homolog 5 (Drosophila) (MADH5), mRNA
D6RBB4 [Target identity:28%; Query identity:100%]
Mothers against decapentaplegic homolog 5
D6RIZ9 [Target identity:27%; Query identity:100%]
Mothers against decapentaplegic homolog 5
D6R9D4 [Target identity:17%; Query identity:100%]
Mothers against decapentaplegic homolog 5

Show » « Hide

Transcription factors
beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001503 [ossification]
GO:0001657 [ureteric bud development]
GO:0001880 [Mullerian duct regression]
GO:0002051 [osteoblast fate commitment]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007281 [germ cell development]
GO:0009880 [embryonic pattern specification]
GO:0016021 [integral to membrane]
GO:0030218 [erythrocyte differentiation]
GO:0030509 [BMP signaling pathway]
GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060048 [cardiac muscle contraction]
GO:0060348 [bone development]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071773 [cellular response to BMP stimulus]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]

464

52.1

SMAD5-202

ENSP00000446474
ENST00000545620

Q99717
Show all » « Hide

Show » « Hide

Transcription factors
beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001657 [ureteric bud development]
GO:0001880 [Mullerian duct regression]
GO:0002051 [osteoblast fate commitment]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007281 [germ cell development]
GO:0009880 [embryonic pattern specification]
GO:0016021 [integral to membrane]
GO:0030218 [erythrocyte differentiation]
GO:0030509 [BMP signaling pathway]
GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060048 [cardiac muscle contraction]
GO:0060348 [bone development]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071773 [cellular response to BMP stimulus]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]

464

52.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.