POMC

GENE INFORMATION

? »

Gene name

POMC (HGNC Symbol)

Synonyms

ACTH, CLIP, LPH, MSH, NPP, POC

Description

Proopiomelanocortin (HGNC Symbol)

Entrez gene summary

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Nov 2014]

Chromosome

2

Cytoband

p23.3

Chromosome location (bp)

25383722 - 25391772

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115138 (version 75.37)

Entrez gene

5443

UniProt

P01189 (UniProt - Evidence at protein level)

neXtProt

NX_P01189

Antibodypedia

POMC antibodies
 

PROTEIN VIEW

? »
 
 
 
POMC-001
 
POMC-002
 
POMC-003
 
POMC-004
 
POMC-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POMC-001 ENSP00000384092
ENST00000405623
P01189
Show all »
Show » Show » 267 29.4 Yes 0
POMC-002 ENSP00000264708
ENST00000264708
P01189
Show all »
Show » Show » 267 29.4 Yes 0
POMC-003 ENSP00000387993
ENST00000449220
E9PHK5
Show all »
Show » Show » 246 27.1 Yes 0
POMC-004 ENSP00000379170
ENST00000395826
P01189
Show all »
Show » Show » 267 29.4 Yes 0
POMC-201 ENSP00000370171
ENST00000380794
P01189
Show all »
Show » Show » 267 29.4 Yes 0