|
GENE INFORMATION
? »
|
The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
|
|
|
|
PROTEIN VIEW
? »
|
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
|
|
|
|
PROTEIN INFORMATION
? »
|
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
|
Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
|
KDM5B-001 |
ENSP00000356234
ENST00000367265
|
Q9UGL1 Show all »
« Hide
Q9UGL1 [Direct mapping]Lysine-specific demethylase 5B Q9UFD3 [Target identity:87%; Query identity:100%]Putative uncharacterized protein DKFZp434N0335 B3KV94 [Target identity:82%; Query identity:100%]Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a; Lysine-specific demethylase 5B; cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA B3KMS8 [Target identity:67%; Query identity:100%]cDNA FLJ12491 fis, clone NT2RM2001605, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA Q9UFC7 [Target identity:66%; Query identity:100%]Putative uncharacterized protein DKFZp434D0815 Q9UIW7 [Target identity:59%; Query identity:100%]Putative uncharacterized protein DKFZp434I0617 Q9NSZ7 [Target identity:40%; Query identity:100%]Putative uncharacterized protein DKFZp434I2412 B3KMS2 [Target identity:26%; Query identity:100%]cDNA FLJ12459 fis, clone NT2RM1000691, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA Q6UGB8 [Target identity:4%; Query identity:100%]Putative DNA/chromatin binding motif
|
Show »
« Hide
THUMBUP predicted membrane proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0034647 [histone demethylase activity (H3-trimethyl-K4 specific)] GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0034721 [histone H3-K4 demethylation, trimethyl-H3-K4-specific] GO:0043231 [intracellular membrane-bounded organelle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process]
|
1544 |
175.7 |
No |
0 |
KDM5B-002 |
ENSP00000235790
ENST00000235790
|
B3KV94 Show all »
« Hide
B3KV94 [Target identity:100%; Query identity:100%]Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a; Lysine-specific demethylase 5B; cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA B3KMS8 [Target identity:81%; Query identity:100%]cDNA FLJ12491 fis, clone NT2RM2001605, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA
|
Show »
« Hide
THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0055114 [oxidation-reduction process]
|
1275 |
145.1 |
No |
0 |
KDM5B-003 |
ENSP00000356233
ENST00000367264
|
Q9UGL1 Show all »
« Hide
Q9UGL1 [Direct mapping]Lysine-specific demethylase 5B B3KMS8 [Target identity:65%; Query identity:100%]cDNA FLJ12491 fis, clone NT2RM2001605, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA Q9UFC7 [Target identity:65%; Query identity:100%]Putative uncharacterized protein DKFZp434D0815 Q9UIW7 [Target identity:57%; Query identity:100%]Putative uncharacterized protein DKFZp434I0617 Q9NSZ7 [Target identity:39%; Query identity:100%]Putative uncharacterized protein DKFZp434I2412 B3KMS2 [Target identity:25%; Query identity:100%]cDNA FLJ12459 fis, clone NT2RM1000691, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA Q6UGB8 [Target identity:4%; Query identity:100%]Putative DNA/chromatin binding motif
|
Show »
« Hide
THUMBUP predicted membrane proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0034647 [histone demethylase activity (H3-trimethyl-K4 specific)] GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0034721 [histone H3-K4 demethylation, trimethyl-H3-K4-specific] GO:0043231 [intracellular membrane-bounded organelle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process]
|
1580 |
179.4 |
No |
0 |
KDM5B-010 |
ENSP00000473481
ENST00000602511
|
R4GN45 Show all »
« Hide
R4GN45 [Target identity:100%; Query identity:100%]Lysine-specific demethylase 5B
|
Show »
« Hide
Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
|
|
77 |
8.8 |
No |
0 |
|
|
|
|
|