GLE1

GENE INFORMATION

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Gene name

GLE1 (HGNC Symbol)

Synonyms

GLE1L, hGLE1, LCCS1

Description

GLE1 RNA export mediator (HGNC Symbol)

Entrez gene summary

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

131266979 - 131304567

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119392 (version 75.37)

Entrez gene

2733

UniProt

Q53GS7 (UniProt - Evidence at protein level)

neXtProt

NX_Q53GS7

Antibodypedia

GLE1 antibodies
 

PROTEIN VIEW

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GLE1-001
 
GLE1-002
 
GLE1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLE1-001 ENSP00000361856
ENST00000372770
Q53GS7
Show all »
Show » Show » 659 75.4 No 0
GLE1-002 ENSP00000308622
ENST00000309971
Q53GS7
Show all »
Show » Show » 698 79.8 No 0
GLE1-201 ENSP00000438670
ENST00000539582
B3KMG0
Show all »
Show » Show » 444 50.4 No 0