HOXB8

GENE INFORMATION

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Gene name

HOXB8 (HGNC Symbol)

Synonyms

HOX2, HOX2D

Description

Homeobox B8 (HGNC Symbol)

Entrez gene summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

46688739 - 46692478

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120068 (version 75.37)

Entrez gene

3218

UniProt

P17481 (UniProt - Evidence at transcript level)

neXtProt

NX_P17481

Antibodypedia

HOXB8 antibodies
 

PROTEIN VIEW

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HOXB8-001
 
HOXB8-002
 
HOXB8-003
 
HOXB8-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HOXB8-001 ENSP00000239144
ENST00000239144
P17481
Show all »
Show » Show » 243 27.6 No 0
HOXB8-002 ENSP00000459303
ENST00000468443
I3L221
Show all »
Show » Show » 33 3.8 No 0
HOXB8-003 ENSP00000460254
ENST00000498634
Show » Show » 128 14.6 No 0
HOXB8-004 ENSP00000460659
ENST00000576562
I3L3R1
Show all »
Show » Show » 242 27.5 No 0