PMS2

GENE INFORMATION

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Gene name

PMS2 (HGNC Symbol)

Synonyms

HNPCC4, H_DJ0042M02.9, PMSL2

Description

PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p22.1

Chromosome location (bp)

6012870 - 6048756

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122512 (version 75.37)

Entrez gene

5395

UniProt

P54278 (UniProt - Evidence at protein level)

neXtProt

NX_P54278

Antibodypedia

PMS2 antibodies
 

PROTEIN VIEW

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PMS2-001
 
PMS2-005
 
PMS2-006
 
PMS2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PMS2-001 ENSP00000265849
ENST00000265849
P54278
Show all »
Show » Show » 862 95.8 No 0
PMS2-005 ENSP00000384308
ENST00000406569
P54278
Show all »
Show » Show » 572 62.8 No 0
PMS2-006 ENSP00000371758
ENST00000382321
P54278
Show all »
Show » Show » 461 51.3 No 0
PMS2-201 ENSP00000392843
ENST00000441476
C9J167
Show all »
Show » Show » 756 84.7 No 0