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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
P4HA1 (HGNC Symbol) |
Synonyms |
C-P4Halpha(I), P4HA |
Description |
Prolyl 4-hydroxylase, alpha polypeptide I (HGNC Symbol) |
Entrez gene summary |
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
Chromosome |
10 |
Cytoband |
q22.1 |
Chromosome location (bp) |
74766975 - 74856732 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000122884 (version 75.37) |
Entrez gene |
5033 |
UniProt |
P13674 (UniProt - Evidence at protein level) |
neXtProt |
NX_P13674 |
Antibodypedia |
P4HA1 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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P4HA1-001 |
ENSP00000307318
ENST00000307116
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P13674 Show all »
« Hide
P13674 [Direct mapping]Prolyl 4-hydroxylase subunit alpha-1
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Show »
« Hide
Oxidoreductases SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0030199 [collagen fibril organization] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
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534 |
61 |
Yes |
0 |
P4HA1-002 |
ENSP00000362099
ENST00000373008
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P13674 Show all »
« Hide
P13674 [Direct mapping]Prolyl 4-hydroxylase subunit alpha-1 Q5VSQ6 [Target identity:100%; Query identity:100%]Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I variant; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_a; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_b
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Show »
« Hide
Oxidoreductases SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0030199 [collagen fibril organization] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
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534 |
61 |
Yes |
0 |
P4HA1-201 |
ENSP00000263556
ENST00000263556
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P13674 Show all »
« Hide
P13674 [Direct mapping]Prolyl 4-hydroxylase subunit alpha-1 Q5VSQ6 [Target identity:100%; Query identity:100%]Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I variant; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_a; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (Proline 4-hydroxylase), alpha polypeptide I, isoform CRA_b
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Show »
« Hide
Oxidoreductases SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0030199 [collagen fibril organization] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
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534 |
61 |
Yes |
0 |
P4HA1-202 |
ENSP00000378353
ENST00000394890
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P13674 Show all »
« Hide
P13674 [Direct mapping]Prolyl 4-hydroxylase subunit alpha-1
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Show »
« Hide
Oxidoreductases SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0030199 [collagen fibril organization] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
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534 |
61 |
Yes |
0 |
P4HA1-203 |
ENSP00000411688
ENST00000412021
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P13674 Show all »
« Hide
P13674 [Direct mapping]Prolyl 4-hydroxylase subunit alpha-1
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Show »
« Hide
Oxidoreductases SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0030199 [collagen fibril organization] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
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534 |
61 |
Yes |
0 |
P4HA1-204 |
ENSP00000414464
ENST00000440381
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P13674 Show all »
« Hide
P13674 [Direct mapping]Prolyl 4-hydroxylase subunit alpha-1
|
Show »
« Hide
Oxidoreductases SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0004656 [procollagen-proline 4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0016491 [oxidoreductase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0030199 [collagen fibril organization] GO:0031418 [L-ascorbic acid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
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516 |
59 |
Yes |
0 |
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