SLC12A5

GENE INFORMATION

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Gene name

SLC12A5 (HGNC Symbol)

Synonyms

KCC2, KIAA1176

Description

Solute carrier family 12 (potassium/chloride transporter), member 5 (HGNC Symbol)

Entrez gene summary

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

44650356 - 44688784

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124140 (version 75.37)

Entrez gene

57468

UniProt

Q9H2X9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9H2X9

Antibodypedia

SLC12A5 antibodies
 

PROTEIN VIEW

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SLC12A5-001
 
SLC12A5-002
 
SLC12A5-003
 
SLC12A5-004
 
SLC12A5-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC12A5-001 ENSP00000361389
ENST00000372315
Q5VZ42
Show all »
Show » Show » 285 30.4 No 5
SLC12A5-002 ENSP00000243964
ENST00000243964
Q9H2X9
Show all »
Show » Show » 1116 123.5 No >9
SLC12A5-003 ENSP00000387694
ENST00000454036
Q9H2X9
Show all »
Show » Show » 1139 126.2 No >9
SLC12A5-004 ENSP00000446091
ENST00000539566
B7Z3T3
Show all »
Show » Show » 186 20 No 2
SLC12A5-005 ENSP00000476885
ENST00000608944
Show » Show » 111 12 No 0