SERPINB6

GENE INFORMATION

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Gene name

SERPINB6 (HGNC Symbol)

Synonyms

CAP, DFNB91, PI6, PTI

Description

Serpin peptidase inhibitor, clade B (ovalbumin), member 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Chromosome

6

Cytoband

p25.2

Chromosome location (bp)

2948393 - 2972090

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124570 (version 75.37)

Entrez gene

5269

UniProt

P35237 (UniProt - Evidence at protein level)

neXtProt

NX_P35237

Antibodypedia

SERPINB6 antibodies
 

PROTEIN VIEW

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SERPINB6-001
 
SERPINB6-002
 
SERPINB6-003
 
SERPINB6-004
 
SERPINB6-005
 
SERPINB6-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINB6-001 ENSP00000369896
ENST00000380524
P35237
Show all »
Show » Show » 376 42.6 No 0
SERPINB6-002 ENSP00000369891
ENST00000380520
P35237
Show all »
Show » Show » 376 42.6 No 0
SERPINB6-003 ENSP00000338358
ENST00000335686
P35237
Show all »
Show » Show » 376 42.6 No 0
SERPINB6-004 ENSP00000369901
ENST00000380529
P35237
Show all »
Show » Show » 376 42.6 No 0
SERPINB6-005 ENSP00000369912
ENST00000380539
P35237
Show all »
Show » Show » 376 42.6 No 0
SERPINB6-006 ENSP00000369919
ENST00000380546
P35237
Show all »
Show » Show » 376 42.6 No 0