PCSK2

GENE INFORMATION

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Gene name

PCSK2 (HGNC Symbol)

Synonyms

NEC2, PC2, SPC2

Description

Proprotein convertase subtilisin/kexin type 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]

Chromosome

20

Cytoband

p12.1

Chromosome location (bp)

17206752 - 17465223

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125851 (version 75.37)

Entrez gene

5126

UniProt

P16519 (UniProt - Evidence at transcript level)

neXtProt

NX_P16519

Antibodypedia

PCSK2 antibodies
 

PROTEIN VIEW

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PCSK2-001
 
PCSK2-002
 
PCSK2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCSK2-001 ENSP00000262545
ENST00000262545
P16519
Show all »
Show » Show » 638 70.6 Yes 0
PCSK2-002 ENSP00000367131
ENST00000377899
P16519
Show all »
Show » Show » 619 68.6 No 0
PCSK2-005 ENSP00000437458
ENST00000536609
P16519
Show all »
Show » Show » 603 66.3 Yes 0