IDUA

GENE INFORMATION

? »

Gene name

IDUA (HGNC Symbol)

Synonyms

MPS1

Description

Iduronidase, alpha-L- (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p16.3

Chromosome location (bp)

980785 - 998316

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000127415 (version 75.37)

Entrez gene

3425

UniProt

P35475 (UniProt - Evidence at protein level)

neXtProt

NX_P35475

Antibodypedia

IDUA antibodies
 

PROTEIN VIEW

? »
 
 
 
IDUA-001
 
IDUA-004
 
IDUA-005
 
IDUA-007
 
IDUA-010
 
IDUA-011
 
IDUA-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDUA-001 ENSP00000247933
ENST00000247933
P35475
Show all »
Show » Show » 653 72.7 Yes 0
IDUA-004 ENSP00000425081
ENST00000514224
D6REB5
Show all »
Show » Show » 521 57.9 No 0
IDUA-005 ENSP00000422952
ENST00000502910
D6R9D5
Show all »
Show » Show » 224 25.2 Yes 0
IDUA-007 ENSP00000424847
ENST00000504568
J9QQV7
Show all »
Show » Show » 196 21.9 No 0
IDUA-010 ENSP00000423685
ENST00000514192
H0Y9B3
Show all »
Show » Show » 232 25.6 No 0
IDUA-011 ENSP00000424227
ENST00000509948
D6RBD5
Show all »
Show » Show » 176 19.8 No 0
IDUA-201 ENSP00000396458
ENST00000453894
B3KWK6
Show all »
Show » Show » 675 73.5 Yes 0