POR - Gene info - The Human Protein Atlas

POR

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

? »

Gene name	POR (HGNC Symbol)
Synonyms	CYPOR, FLJ26468
Description	P450 (cytochrome) oxidoreductase (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	75528518 - 75616173
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127948 (version 75.37)
Entrez gene	5447
UniProt	P16435 (UniProt - Evidence at protein level)
neXtProt	NX_P16435
Antibodypedia	POR antibodies

PROTEIN VIEW

? »

POR-001		POR-002		POR-003		POR-004		POR-006		POR-007		POR-009		POR-013		POR-014		POR-015		POR-017		POR-018		POR-019		POR-020		POR-021		POR-022		POR-024		POR-201		POR-202		POR-203

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
POR-001	ENSP00000419970 ENST00000461988	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase Q59ED7 [Target identity:100%; Query identity:99%] NADPH--cytochrome P450 reductase E7EMD0 [Target identity:61%; Query identity:100%] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:5%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0008941 [nitric oxide dioxygenase activity] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071371 [cellular response to gonadotropin stimulus] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090181 [regulation of cholesterol metabolic process] GO:0090346 [cellular organofluorine metabolic process]	680	77	No	1
POR-002	ENSP00000409238 ENST00000412521	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:26%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	146	16.4	No	1
POR-003	ENSP00000399327 ENST00000414186	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:22%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	172	19.3	No	1
POR-004	ENSP00000389719 ENST00000418341	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:62%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	62	7.1	No	1
POR-006	ENSP00000403494 ENST00000439297	C9JDE2 Show all » « Hide C9JDE2 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		54	6.1	No	0
POR-007	ENSP00000399409 ENST00000448410	E7EWU0 Show all » « Hide E7EWU0 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:38%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005739 [mitochondrion] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process]	101	11.7	No	1
POR-009	ENSP00000378355 ENST00000394893	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:6%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	633	71.6	No	1
POR-013	ENSP00000414263 ENST00000454934	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:20%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	189	21	No	1
POR-014	ENSP00000393527 ENST00000447222	E7EVY7 Show all » « Hide E7EVY7 [Target identity:79%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005506 [iron ion binding] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	725	81.6	No	0
POR-015	ENSP00000412490 ENST00000439269	E7EMD0 Show all » « Hide E7EMD0 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005739 [mitochondrion] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process]	418	47.4	No	0
POR-017	ENSP00000395813 ENST00000453773	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:27%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	140	15.8	No	1
POR-018	ENSP00000390540 ENST00000439963	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:20%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	188	21.1	No	1
POR-019	ENSP00000409881 ENST00000421059	C9JQ78 Show all » « Hide C9JQ78 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005739 [mitochondrion] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process]	39	4.2	No	0
POR-020	ENSP00000389409 ENST00000432753	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:23%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	166	18.7	No	1
POR-021	ENSP00000399556 ENST00000449920	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:62%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	62	7.1	No	1
POR-022	ENSP00000400964 ENST00000426184	C9JU80 Show all » « Hide C9JU80 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005506 [iron ion binding] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity]	108	12	No	0
POR-024	ENSP00000404731 ENST00000412064	P16435 Show all » « Hide P16435 [Direct mapping] NADPH--cytochrome P450 reductase C9JQ78 [Target identity:18%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Oxidoreductases 1TM proteins predicted by MDM TMHMM predicted membrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032770 [positive regulation of monooxygenase activity] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process] GO:0090346 [cellular organofluorine metabolic process]	211	23.4	No	1
POR-201	ENSP00000414244 ENST00000419840	E7EPN3 Show all » « Hide E7EPN3 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	368	41.4	No	0
POR-202	ENSP00000416572 ENST00000450476	E7EVY7 Show all » « Hide E7EVY7 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005506 [iron ion binding] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	573	64.5	No	0
POR-203	ENSP00000446149 ENST00000545601	F5H468 Show all » « Hide F5H468 [Target identity:100%; Query identity:100%] NADPH--cytochrome P450 reductase E7EMD0 [Target identity:85%; Query identity:100%] NADPH--cytochrome P450 reductase	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation] GO:0003958 [NADPH-hemoprotein reductase activity] GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H] GO:0005739 [mitochondrion] GO:0007584 [response to nutrient] GO:0009055 [electron carrier activity] GO:0009437 [carnitine metabolic process] GO:0009812 [flavonoid metabolic process] GO:0010181 [FMN binding] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0016787 [hydrolase activity] GO:0018393 [internal peptidyl-lysine acetylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043602 [nitrate catabolic process] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0046210 [nitric oxide catabolic process] GO:0047726 [iron-cytochrome-c reductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] GO:0060192 [negative regulation of lipase activity] GO:0070988 [demethylation] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090031 [positive regulation of steroid hormone biosynthetic process]	488	55.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.