RNASE1

GENE INFORMATION

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Gene name

RNASE1 (HGNC Symbol)

Synonyms

RNS1

Description

Ribonuclease, RNase A family, 1 (pancreatic) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

21269387 - 21271437

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129538 (version 75.37)

Entrez gene

6035

UniProt

P07998 (UniProt - Evidence at protein level)

neXtProt

NX_P07998

Antibodypedia

RNASE1 antibodies
 

PROTEIN VIEW

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RNASE1-001
 
RNASE1-002
 
RNASE1-003
 
RNASE1-004
 
RNASE1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RNASE1-001 ENSP00000381057
ENST00000397967
P07998
Show all »
Show » Show » 156 17.6 Yes 0
RNASE1-002 ENSP00000344193
ENST00000340900
P07998
Show all »
Show » Show » 156 17.6 Yes 0
RNASE1-003 ENSP00000381060
ENST00000397970
P07998
Show all »
Show » Show » 156 17.6 Yes 0
RNASE1-004 ENSP00000399493
ENST00000412779
P07998
Show all »
Show » Show » 156 17.6 Yes 0
RNASE1-005 ENSP00000451058
ENST00000555698
G3V357
Show all »
Show » Show » 116 13 No 0