NFATC1 - Gene info - The Human Protein Atlas

NFATC1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	NFATC1 (HGNC Symbol)
Synonyms	NF-ATC, NFAT2, NFATc
Description	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (HGNC Symbol)
Entrez gene summary	The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Chromosome	18
Cytoband	q23
Chromosome location (bp)	77155856 - 77289325
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131196 (version 75.37)
Entrez gene	4772
UniProt	O95644 (UniProt - Evidence at protein level)
neXtProt	NX_O95644
Antibodypedia	NFATC1 antibodies

PROTEIN VIEW

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NFATC1-001		NFATC1-002		NFATC1-003		NFATC1-004		NFATC1-005		NFATC1-006		NFATC1-007		NFATC1-008		NFATC1-009		NFATC1-010		NFATC1-011		NFATC1-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NFATC1-001	ENSP00000253506 ENST00000253506	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	825	88.8	No	0
NFATC1-002	ENSP00000380892 ENST00000397790	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	353	38.6	No	0
NFATC1-003	ENSP00000316553 ENST00000318065	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	812	87.9	No	0
NFATC1-004	ENSP00000466194 ENST00000591814	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	716	77.8	No	0
NFATC1-005	ENSP00000468111 ENST00000587635	K7ER53 Show all » « Hide K7ER53 [Target identity:100%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]	639	69.4	No	0
NFATC1-006	ENSP00000442435 ENST00000542384	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	713	77.4	No	0
NFATC1-007	ENSP00000389377 ENST00000427363	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1 F5H4S8 [Target identity:49%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	943	101.2	No	0
NFATC1-008	ENSP00000467615 ENST00000590313	K7EQ04 Show all » « Hide K7EQ04 [Target identity:100%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		71	7.8	No	0
NFATC1-009	ENSP00000327850 ENST00000329101	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1 F5H4S8 [Target identity:50%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0010628 [positive regulation of gene expression] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	930	100.3	No	0
NFATC1-010	ENSP00000466489 ENST00000586434	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	700	76.5	No	0
NFATC1-011	ENSP00000467181 ENST00000592223	O95644 Show all » « Hide O95644 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 1	Show » « Hide Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001205 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048273 [mitogen-activated protein kinase p38 binding]	703	76.9	No	0
NFATC1-201	ENSP00000439992 ENST00000545796	F5H4S8 Show all » « Hide F5H4S8 [Target identity:100%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001837 [epithelial to mesenchymal transition] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006816 [calcium ion transport] GO:0007507 [heart development] GO:0030316 [osteoclast differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	471	51.1	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.