FMO5

GENE INFORMATION

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Gene name

FMO5

Synonyms

Description

Flavin containing monooxygenase 5 (HGNC Symbol)

Entrez gene summary

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Chromosome

1

Cytoband

q21.1

Chromosome location (bp)

146646930 - 146714700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131781 (version 75.37)

Entrez gene

2330

UniProt

P49326 (UniProt - Evidence at transcript level)

neXtProt

NX_P49326

Antibodypedia

FMO5 antibodies
 

PROTEIN VIEW

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FMO5-001
 
FMO5-004
 
FMO5-005
 
FMO5-006
 
FMO5-007
 
FMO5-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FMO5-001 ENSP00000254090
ENST00000254090
P49326
Show all »
Show » Show » 533 60.2 Yes 1
FMO5-004 ENSP00000358277
ENST00000369272
P49326
Show all »
Show » Show » 285 32.5 No 0
FMO5-005 ENSP00000433742
ENST00000527849
E9PJF3
Show all »
Show » Show » 278 31.7 No 0
FMO5-006 ENSP00000432569
ENST00000533848
E9PQ84
Show all »
Show » Show » 145 16.6 Yes 0
FMO5-007 ENSP00000436429
ENST00000533174
E9PP51
Show all »
Show » Show » 192 21.9 No 0
FMO5-009 ENSP00000416011
ENST00000441068
P49326
Show all »
Show » Show » 464 52.5 No 0