RAMP1

GENE INFORMATION

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Gene name

RAMP1

Synonyms

Description

Receptor (G protein-coupled) activity modifying protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.3

Chromosome location (bp)

238767536 - 238820756

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132329 (version 75.37)

Entrez gene

10267

UniProt

O60894 (UniProt - Evidence at protein level)

neXtProt

NX_O60894

Antibodypedia

RAMP1 antibodies
 

PROTEIN VIEW

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RAMP1-001
 
RAMP1-002
 
RAMP1-003
 
RAMP1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAMP1-001 ENSP00000254661
ENST00000254661
O60894
Show all »
Show » Show » 148 17 Yes 1
RAMP1-002 ENSP00000386046
ENST00000403885
E9PC20
Show all »
Show » Show » 126 14.4 No 1
RAMP1-003 ENSP00000384688
ENST00000404910
E9PC20
Show all »
Show » Show » 126 14.4 No 1
RAMP1-004 ENSP00000386720
ENST00000409726
E9PC20
Show all »
Show » Show » 126 14.4 No 1