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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
LARS (HGNC Symbol) |
Synonyms |
FLJ10595, FLJ21788, HSPC192, LARS1, LEUS, RNTLS |
Description |
Leucyl-tRNA synthetase (HGNC Symbol) |
Entrez gene summary |
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008] |
Chromosome |
5 |
Cytoband |
q32 |
Chromosome location (bp) |
145492601 - 145562223 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000133706 (version 75.37) |
Entrez gene |
51520 |
UniProt |
Q9P2J5 (UniProt - Evidence at protein level) |
neXtProt |
NX_Q9P2J5 |
Antibodypedia |
LARS antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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LARS-001 |
ENSP00000377954
ENST00000394434
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Q9P2J5 Show all »
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Q9P2J5 [Direct mapping]Leucine--tRNA ligase, cytoplasmic B4DJ10 [Target identity:95%; Query identity:100%]Leucine--tRNA ligase, cytoplasmic; cDNA FLJ58533, highly similar to Leucyl-tRNA synthetase, cytoplasmic Q2TU79 [Target identity:41%; Query identity:100%]Cell proliferation-inducing protein 57; Proliferation-inducing protein 44 Q9HAM7 [Target identity:37%; Query identity:100%]cDNA FLJ11351 fis, clone HEMBA1000012, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE Q9NPU8 [Target identity:35%; Query identity:100%]Putative uncharacterized protein DKFZp762P233 B3KXA9 [Target identity:28%; Query identity:100%]cDNA FLJ45065 fis, clone BRAWH3024506, highly similar to Leucyl-tRNA synthetase, cytoplasmic Q9NVC0 [Target identity:20%; Query identity:100%]cDNA FLJ10820 fis, clone NT2RP4001041, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE
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Ligase Enzymes ENZYME proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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1176 |
134.5 |
No |
0 |
LARS-002 |
ENSP00000426005
ENST00000510191
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B4DJ10 Show all »
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B4DJ10 [Target identity:100%; Query identity:100%]Leucine--tRNA ligase, cytoplasmic; cDNA FLJ58533, highly similar to Leucyl-tRNA synthetase, cytoplasmic Q2TU79 [Target identity:43%; Query identity:100%]Cell proliferation-inducing protein 57; Proliferation-inducing protein 44 Q9HAM7 [Target identity:39%; Query identity:100%]cDNA FLJ11351 fis, clone HEMBA1000012, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE Q9NPU8 [Target identity:37%; Query identity:100%]Putative uncharacterized protein DKFZp762P233 B3KXA9 [Target identity:29%; Query identity:100%]cDNA FLJ45065 fis, clone BRAWH3024506, highly similar to Leucyl-tRNA synthetase, cytoplasmic Q9NVC0 [Target identity:21%; Query identity:100%]cDNA FLJ10820 fis, clone NT2RP4001041, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE
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SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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1122 |
128 |
No |
0 |
LARS-201 |
ENSP00000274562
ENST00000274562
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B4DER1 Show all »
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B4DER1 [Target identity:100%; Query identity:100%]Leucine--tRNA ligase, cytoplasmic; cDNA FLJ58157, highly similar to Leucyl-tRNA synthetase, cytoplasmic Q2TU79 [Target identity:42%; Query identity:100%]Cell proliferation-inducing protein 57; Proliferation-inducing protein 44 Q9HAM7 [Target identity:38%; Query identity:100%]cDNA FLJ11351 fis, clone HEMBA1000012, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE Q9NPU8 [Target identity:36%; Query identity:100%]Putative uncharacterized protein DKFZp762P233 B3KXA9 [Target identity:29%; Query identity:100%]cDNA FLJ45065 fis, clone BRAWH3024506, highly similar to Leucyl-tRNA synthetase, cytoplasmic Q9NVC0 [Target identity:21%; Query identity:100%]cDNA FLJ10820 fis, clone NT2RP4001041, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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1149 |
131.5 |
No |
0 |
LARS-202 |
ENSP00000437791
ENST00000545646
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F5H698 Show all »
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F5H698 [Target identity:100%; Query identity:100%]Leucine--tRNA ligase, cytoplasmic Q2TU79 [Target identity:42%; Query identity:100%]Cell proliferation-inducing protein 57; Proliferation-inducing protein 44 Q9HAM7 [Target identity:38%; Query identity:100%]cDNA FLJ11351 fis, clone HEMBA1000012, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE Q9NPU8 [Target identity:37%; Query identity:100%]Putative uncharacterized protein DKFZp762P233 B3KXA9 [Target identity:29%; Query identity:100%]cDNA FLJ45065 fis, clone BRAWH3024506, highly similar to Leucyl-tRNA synthetase, cytoplasmic Q9NVC0 [Target identity:21%; Query identity:100%]cDNA FLJ10820 fis, clone NT2RP4001041, weakly similar to PROBABLE LEUCYL-TRNA SYNTHETASE
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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1130 |
129.2 |
No |
0 |
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