DCTN3

GENE INFORMATION

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Gene name

DCTN3 (HGNC Symbol)

Synonyms

DCTN-22

Description

Dynactin 3 (p22) (HGNC Symbol)

Entrez gene summary

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

34613548 - 34620515

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137100 (version 75.37)

Entrez gene

11258

UniProt

O75935 (UniProt - Evidence at protein level)

neXtProt

NX_O75935

Antibodypedia

DCTN3 antibodies
 

PROTEIN VIEW

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DCTN3-003
 
DCTN3-004
 
DCTN3-007
 
DCTN3-008
 
DCTN3-009
 
DCTN3-010
 
DCTN3-201
 
DCTN3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCTN3-003 ENSP00000390842
ENST00000421919
Show » 151 17.3 No 0
DCTN3-004 ENSP00000432915
ENST00000477738
Show » 176 20 No 0
DCTN3-007 ENSP00000368191
ENST00000378911
F8W786
Show all »
Show » 161 18.2 No 0
DCTN3-008 ENSP00000259632
ENST00000259632
O75935
Show all »
Show » Show » 186 21.1 No 0
DCTN3-009 ENSP00000343986
ENST00000341694
O75935
Show all »
Show » Show » 176 19.5 No 0
DCTN3-010 ENSP00000368193
ENST00000378913
Show » 142 16.1 No 0
DCTN3-201 ENSP00000368196
ENST00000378916
O75935
Show all »
Show » Show » 158 18 No 0
DCTN3-202 ENSP00000397046
ENST00000447983
Q8NB28
Show all »
Show » 172 19.4 No 0