TPMT

GENE INFORMATION

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Gene name

TPMT

Synonyms

Description

Thiopurine S-methyltransferase (HGNC Symbol)

Entrez gene summary

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

Chromosome

6

Cytoband

p22.3

Chromosome location (bp)

18128542 - 18155305

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137364 (version 75.37)

Entrez gene

7172

UniProt

P51580 (UniProt - Evidence at protein level)

neXtProt

NX_P51580

Antibodypedia

TPMT antibodies
 

PROTEIN VIEW

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TPMT-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPMT-001 ENSP00000312304
ENST00000309983
P51580
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