ARRB1

GENE INFORMATION

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Gene name

ARRB1 (HGNC Symbol)

Synonyms

ARR1

Description

Arrestin, beta 1 (HGNC Symbol)

Entrez gene summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Chromosome

11

Cytoband

q13.4

Chromosome location (bp)

74975226 - 75062873

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137486 (version 75.37)

Entrez gene

408

UniProt

P49407 (UniProt - Evidence at protein level)

neXtProt

NX_P49407

Antibodypedia

ARRB1 antibodies
 

PROTEIN VIEW

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ARRB1-001
 
ARRB1-002
 
ARRB1-004
 
ARRB1-005
 
ARRB1-006
 
ARRB1-007
 
ARRB1-012
 
ARRB1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARRB1-001 ENSP00000409581
ENST00000420843
P49407
Show all »
Show » Show » 418 47.1 No 0
ARRB1-002 ENSP00000353124
ENST00000360025
P49407
Show all »
Show » Show » 410 46.3 No 0
ARRB1-004 ENSP00000434196
ENST00000524400
Show » 69 7.7 No 0
ARRB1-005 ENSP00000436352
ENST00000533609
H0YEQ2
Show all »
Show » 59 6.4 No 0
ARRB1-006 ENSP00000433171
ENST00000532525
E9PM35
Show all »
Show » Show » 258 29.2 No 0
ARRB1-007 ENSP00000433137
ENST00000527385
Show » 72 7.9 No 0
ARRB1-012 ENSP00000436530
ENST00000532447
Show » 195 21.8 No 0
ARRB1-201 ENSP00000377141
ENST00000393505
J3KPP7
Show all »
Show » Show » 418 47.2 No 0