PCSK6

GENE INFORMATION

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Gene name

PCSK6 (HGNC Symbol)

Synonyms

PACE4, SPC4

Description

Proprotein convertase subtilisin/kexin type 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

Chromosome

15

Cytoband

q26.3

Chromosome location (bp)

101840818 - 102065405

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140479 (version 75.37)

Entrez gene

5046

UniProt

P29122 (UniProt - Evidence at protein level)

neXtProt

NX_P29122

Antibodypedia

PCSK6 antibodies
 

PROTEIN VIEW

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PCSK6-008
 
PCSK6-010
 
PCSK6-011
 
PCSK6-012
 
PCSK6-017
 
PCSK6-201
 
PCSK6-202
 
PCSK6-203
 
PCSK6-204
 
PCSK6-205
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCSK6-008 ENSP00000381246
ENST00000398185
H0Y3Q0
Show all »
Show » Show » 797 88.6 No 0
PCSK6-010 ENSP00000452997
ENST00000559417
Show » Show » 345 38 No 0
PCSK6-011 ENSP00000452839
ENST00000558864
Show » 77 8.3 No 0
PCSK6-012 ENSP00000453771
ENST00000558951
H0YMW5
Show all »
Show » Show » 125 14.1 No 0
PCSK6-017 ENSP00000453155
ENST00000559605
Show » 126 13.1 No 0
PCSK6-201 ENSP00000332052
ENST00000331826
H7BXT3
Show all »
Show » Show » 498 55 No 0
PCSK6-202 ENSP00000344410
ENST00000344273
E7EQ62
Show all »
Show » Show » 651 71.7 No 0
PCSK6-203 ENSP00000305056
ENST00000348070
P29122
Show all »
Show » Show » 968 106.3 No 0
PCSK6-204 ENSP00000351193
ENST00000358417
E7EM82
Show all »
Show » Show » 955 105 No 0
PCSK6-205 ENSP00000381243
ENST00000398181
E7EWH5
Show all »
Show » Show » 622 68.1 No 0