SIRT3

GENE INFORMATION

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Gene name

SIRT3 (HGNC Symbol)

Synonyms

SIR2L3

Description

Sirtuin 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

215458 - 236931

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142082 (version 75.37)

Entrez gene

23410

UniProt

Q9NTG7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NTG7

Antibodypedia

SIRT3 antibodies
 

PROTEIN VIEW

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 « 
 
SIRT3-001
 
SIRT3-002
 
SIRT3-003
 
SIRT3-004
 
SIRT3-005
 
SIRT3-006
 
SIRT3-008
 
SIRT3-009
 
SIRT3-010
 
SIRT3-011
 
SIRT3-014
 
SIRT3-015
 
SIRT3-016
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIRT3-001 ENSP00000372191
ENST00000382743
Q9NTG7
Show all »
Show » Show » 399 43.6 No 0
SIRT3-002 ENSP00000432937
ENST00000524564
E9PN58
Show all »
Show » Show » 353 39.2 No 0
SIRT3-003 ENSP00000435464
ENST00000525319
E9PK80
Show all »
Show » Show » 318 35.1 No 0
SIRT3-004 ENSP00000433077
ENST00000532956
E9PM75
Show all »
Show » Show » 345 37.6 No 0
SIRT3-005 ENSP00000433899
ENST00000532837
E9PIT6
Show all »
Show » 46 5 No 0
SIRT3-006 ENSP00000434747
ENST00000529937
B7WNN4
Show all »
Show » Show » 134 14.5 No 0
SIRT3-008 ENSP00000437216
ENST00000529382
Q9NTG7
Show all »
Show » Show » 257 28.6 No 0
SIRT3-009 ENSP00000432857
ENST00000528469
E9PNA0
Show all »
Show » Show » 93 10.7 No 0
SIRT3-010 ENSP00000436085
ENST00000525237
Show » Show » 18 1.8 No 0
SIRT3-011 ENSP00000433132
ENST00000525776
E9PM52
Show all »
Show » Show » 23 2.3 No 0
SIRT3-014 ENSP00000435014
ENST00000530067
E9PIT6
Show all »
Show » 46 5 No 0
SIRT3-015 ENSP00000437179
ENST00000529055
E9PIT6
Show all »
Show » 46 5 No 0
SIRT3-016 ENSP00000435505
ENST00000526854
E9PJS6
Show all »
Show » 95 10.4 No 0