PTPRF

GENE INFORMATION

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Gene name

PTPRF (HGNC Symbol)

Synonyms

LAR

Description

Protein tyrosine phosphatase, receptor type, F (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p34.2

Chromosome location (bp)

43990858 - 44089343

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142949 (version 75.37)

Entrez gene

5792

UniProt

P10586 (UniProt - Evidence at protein level)

neXtProt

NX_P10586

Antibodypedia

PTPRF antibodies
 

PROTEIN VIEW

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PTPRF-001
 
PTPRF-002
 
PTPRF-005
 
PTPRF-006
 
PTPRF-013
 
PTPRF-014
 
PTPRF-015
 
PTPRF-201
 
PTPRF-202
 
PTPRF-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRF-001 ENSP00000353030
ENST00000359947
P10586
Show all »
Show » Show » 1907 212.9 Yes 1
PTPRF-002 ENSP00000398822
ENST00000438120
P10586
Show all »
Show » Show » 1898 211.7 Yes 1
PTPRF-005 ENSP00000361484
ENST00000372407
H0Y380
Show all »
Show » Show » 979 111.2 No 1
PTPRF-006 ENSP00000416343
ENST00000414879
F2Z3B8
Show all »
Show » Show » 1332 150.4 No 1
PTPRF-013 ENSP00000413306
ENST00000437607
A2A437
Show all »
Show » Show » 262 28 Yes 0
PTPRF-014 ENSP00000391764
ENST00000412568
H0Y380
Show all »
Show » Show » 1291 145.6 No 1
PTPRF-015 ENSP00000408952
ENST00000429895
Show » Show » 1553 174.8 No 1
PTPRF-201 ENSP00000361490
ENST00000372413
P10586
Show all »
Show » Show » 1898 211.7 Yes 1
PTPRF-202 ENSP00000361491
ENST00000372414
P10586
Show all »
Show » Show » 1907 212.9 Yes 1
PTPRF-203 ENSP00000387885
ENST00000422171
F2Z3B8
Show all »
Show » Show » 1266 143.3 No 1