HSPD1 - Gene info - The Human Protein Atlas

Gene name

HSPD1 (HGNC Symbol)

Synonyms

GROEL, HSP60, SPG13

Description

Heat shock 60kDa protein 1 (chaperonin) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

Chromosome

Cytoband

q33.1

Chromosome location (bp)

198351305 - 198381461

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144381 (version 75.37)

Entrez gene

3329

UniProt

P10809 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSPD1-001

ENSP00000373620
ENST00000388968

P10809
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P10809 [Direct mapping]
60 kDa heat shock protein, mitochondrial
Q53SE2 [Target identity:40%; Query identity:100%]
Putative uncharacterized protein HSPD1
E7EXB4 [Target identity:38%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JCQ4 [Target identity:16%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JL19 [Target identity:14%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9J0S9 [Target identity:10%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
Q53QD5 [Target identity:9%; Query identity:100%]
Putative uncharacterized protein HSPD1

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Plasma proteins
Mitochondrial proteins
Cancer-related genes
Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002368 [B cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006200 [ATP catabolic process]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0009986 [cell surface]
GO:0016887 [ATPase activity]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]

573

61.1

HSPD1-006

ENSP00000412717
ENST00000452200

E7EXB4
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E7EXB4 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JCQ4 [Target identity:42%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JL19 [Target identity:37%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9J0S9 [Target identity:26%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005886 [plasma membrane]
GO:0030141 [secretory granule]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0042110 [T cell activation]
GO:0044267 [cellular protein metabolic process]
GO:0050870 [positive regulation of T cell activation]

221

23.8

HSPD1-007

ENSP00000390404
ENST00000440114

F8WBB1
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F8WBB1 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

5.5

HSPD1-009

ENSP00000414446
ENST00000426480

C9JL25
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C9JL25 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JCQ4 [Target identity:53%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JL19 [Target identity:47%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9J0S9 [Target identity:33%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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175

19.2

HSPD1-010

ENSP00000396460
ENST00000428204

C9JCQ4
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C9JCQ4 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JL19 [Target identity:88%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9J0S9 [Target identity:61%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005524 [ATP binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005886 [plasma membrane]
GO:0030141 [secretory granule]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0042110 [T cell activation]
GO:0044267 [cellular protein metabolic process]
GO:0050870 [positive regulation of T cell activation]

10.3

HSPD1-011

ENSP00000402478
ENST00000439605

C9JL19
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C9JL19 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9J0S9 [Target identity:69%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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HSPD1-012

ENSP00000412227
ENST00000418022

C9J0S9
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C9J0S9 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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6.4

HSPD1-013

ENSP00000393670
ENST00000430176

E7ESH4
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E7ESH4 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JCQ4 [Target identity:40%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JL19 [Target identity:35%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9J0S9 [Target identity:24%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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234

25.2

HSPD1-201

ENSP00000340019
ENST00000345042

P10809
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GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002368 [B cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006200 [ATP catabolic process]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0009986 [cell surface]
GO:0016887 [ATPase activity]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]

573

61.1

HSPD1-202

ENSP00000441296
ENST00000544407

B7Z712
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B7Z712 [Target identity:100%; Query identity:100%]
60 kDa heat shock protein, mitochondrial; cDNA FLJ52281, highly similar to 60 kDa heat shock protein, mitochondrial
C9JCQ4 [Target identity:59%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9JL19 [Target identity:52%; Query identity:100%]
60 kDa heat shock protein, mitochondrial
C9J0S9 [Target identity:36%; Query identity:100%]
60 kDa heat shock protein, mitochondrial

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005886 [plasma membrane]
GO:0006950 [response to stress]
GO:0030141 [secretory granule]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0042110 [T cell activation]
GO:0044267 [cellular protein metabolic process]
GO:0050870 [positive regulation of T cell activation]

158

17.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.