NDUFS6

GENE INFORMATION

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Gene name

NDUFS6 (HGNC Symbol)

Synonyms

CI-13kA

Description

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

1801514 - 1816719

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145494 (version 75.37)

Entrez gene

4726

UniProt

O75380 (UniProt - Evidence at protein level)

neXtProt

NX_O75380

Antibodypedia

NDUFS6 antibodies
 

PROTEIN VIEW

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NDUFS6-001
 
NDUFS6-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDUFS6-001 ENSP00000274137
ENST00000274137
O75380
Show all »
Show » Show » 124 13.7 No 0
NDUFS6-002 ENSP00000422557
ENST00000469176
D6RBT3
Show all »
Show » 172 18.8 No 0