PIK3R1 - Gene info - The Human Protein Atlas

PIK3R1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PIK3R1 (HGNC Symbol)
Synonyms	GRB1, p85, p85-ALPHA
Description	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (HGNC Symbol)
Entrez gene summary	Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Chromosome	5
Cytoband	q13.1
Chromosome location (bp)	67511548 - 67597649
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145675 (version 75.37)
Entrez gene	5295
UniProt	P27986 (UniProt - Evidence at protein level)
neXtProt	NX_P27986
Antibodypedia	PIK3R1 antibodies

PROTEIN VIEW

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PIK3R1-001		PIK3R1-002		PIK3R1-003		PIK3R1-004		PIK3R1-009		PIK3R1-010		PIK3R1-011		PIK3R1-012		PIK3R1-014		PIK3R1-015		PIK3R1-016		PIK3R1-201		PIK3R1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PIK3R1-001	ENSP00000428056 ENST00000521381	P27986 Show all » « Hide P27986 [Direct mapping] Phosphatidylinositol 3-kinase regulatory subunit alpha B3KWZ7 [Target identity:55%; Query identity:100%] cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha J7GU64 [Target identity:36%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit J7GXU7 [Target identity:36%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit E5RJY0 [Target identity:18%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RGI8 [Target identity:16%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RHI0 [Target identity:14%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003924 [GTPase activity] GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005943 [1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex] GO:0006468 [protein phosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043125 [ErbB-3 class receptor binding] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0043559 [insulin binding] GO:0043560 [insulin receptor substrate binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050852 [T cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051531 [NFAT protein import into nucleus] GO:0060396 [growth hormone receptor signaling pathway] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]	724	83.6	No	0
PIK3R1-002	ENSP00000323512 ENST00000320694	P27986 Show all » « Hide P27986 [Direct mapping] Phosphatidylinositol 3-kinase regulatory subunit alpha B3KWZ7 [Target identity:95%; Query identity:100%] cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha J7GU64 [Target identity:62%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit J7GXU7 [Target identity:62%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit E5RJY0 [Target identity:32%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003924 [GTPase activity] GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005943 [1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex] GO:0006468 [protein phosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043125 [ErbB-3 class receptor binding] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0043559 [insulin binding] GO:0043560 [insulin receptor substrate binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050852 [T cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051531 [NFAT protein import into nucleus] GO:0060396 [growth hormone receptor signaling pathway] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]	424	50	No	0
PIK3R1-003	ENSP00000338554 ENST00000336483	P27986 Show all » « Hide P27986 [Direct mapping] Phosphatidylinositol 3-kinase regulatory subunit alpha B3KWZ7 [Target identity:88%; Query identity:100%] cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha J7GU64 [Target identity:58%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit J7GXU7 [Target identity:57%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit E5RJY0 [Target identity:30%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003924 [GTPase activity] GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005943 [1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex] GO:0006468 [protein phosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043125 [ErbB-3 class receptor binding] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0043559 [insulin binding] GO:0043560 [insulin receptor substrate binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050852 [T cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051531 [NFAT protein import into nucleus] GO:0060396 [growth hormone receptor signaling pathway] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]	454	53.5	No	0
PIK3R1-004	ENSP00000430098 ENST00000523872	P27986 Show all » « Hide P27986 [Direct mapping] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RJY0 [Target identity:37%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003924 [GTPase activity] GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005943 [1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex] GO:0006468 [protein phosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043125 [ErbB-3 class receptor binding] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0043559 [insulin binding] GO:0043560 [insulin receptor substrate binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050852 [T cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051531 [NFAT protein import into nucleus] GO:0060396 [growth hormone receptor signaling pathway] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]	361	42.8	No	0
PIK3R1-009	ENSP00000430126 ENST00000523807	E5RGI8 Show all » « Hide E5RGI8 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RHI0 [Target identity:87%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0005515 [protein binding] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043560 [insulin receptor substrate binding] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051531 [NFAT protein import into nucleus]	117	13.3	No	0
PIK3R1-010	ENSP00000429766 ENST00000522084	E5RHI0 Show all » « Hide E5RHI0 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0005515 [protein binding] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043560 [insulin receptor substrate binding] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051531 [NFAT protein import into nucleus]	102	11.5	No	0
PIK3R1-011	ENSP00000431058 ENST00000521409	E5RJY0 Show all » « Hide E5RJY0 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0005515 [protein binding] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043560 [insulin receptor substrate binding] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051531 [NFAT protein import into nucleus]	137	16.3	No	0
PIK3R1-012	ENSP00000430424 ENST00000517698	E5RK66 Show all » « Hide E5RK66 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		38	4.5	No	0
PIK3R1-014	ENSP00000428566 ENST00000520675	H0YB27 Show all » « Hide H0YB27 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005622 [intracellular] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0007165 [signal transduction] GO:0035014 [phosphatidylinositol 3-kinase regulator activity]	132	14.8	No	0
PIK3R1-015	ENSP00000429156 ENST00000519025	H0YBC2 Show all » « Hide H0YBC2 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RJY0 [Target identity:72%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0005515 [protein binding] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0006468 [protein phosphorylation] GO:0016020 [membrane] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043560 [insulin receptor substrate binding] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051531 [NFAT protein import into nucleus]	189	22.4	No	0
PIK3R1-016	ENSP00000429277 ENST00000521657	P27986 Show all » « Hide P27986 [Direct mapping] Phosphatidylinositol 3-kinase regulatory subunit alpha B3KWZ7 [Target identity:55%; Query identity:100%] cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha J7GU64 [Target identity:36%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit J7GXU7 [Target identity:36%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit E5RJY0 [Target identity:18%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RGI8 [Target identity:16%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RHI0 [Target identity:14%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003924 [GTPase activity] GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005943 [1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex] GO:0006468 [protein phosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043125 [ErbB-3 class receptor binding] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0043559 [insulin binding] GO:0043560 [insulin receptor substrate binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050852 [T cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051531 [NFAT protein import into nucleus] GO:0060396 [growth hormone receptor signaling pathway] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]	724	83.6	No	0
PIK3R1-201	ENSP00000274335 ENST00000274335	P27986 Show all » « Hide P27986 [Direct mapping] Phosphatidylinositol 3-kinase regulatory subunit alpha B3KWZ7 [Target identity:55%; Query identity:100%] cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha J7GU64 [Target identity:36%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit J7GXU7 [Target identity:36%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit E5RJY0 [Target identity:18%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RGI8 [Target identity:16%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RHI0 [Target identity:14%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003924 [GTPase activity] GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005943 [1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex] GO:0006468 [protein phosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043125 [ErbB-3 class receptor binding] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0043559 [insulin binding] GO:0043560 [insulin receptor substrate binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050852 [T cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051531 [NFAT protein import into nucleus] GO:0060396 [growth hormone receptor signaling pathway] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]	724	83.6	No	0
PIK3R1-202	ENSP00000379855 ENST00000396611	P27986 Show all » « Hide P27986 [Direct mapping] Phosphatidylinositol 3-kinase regulatory subunit alpha J7GU64 [Target identity:36%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit J7GXU7 [Target identity:35%; Query identity:100%] Phosphoinositide-3-kinase regulatory subunit E5RJY0 [Target identity:18%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RGI8 [Target identity:15%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha E5RHI0 [Target identity:13%; Query identity:100%] Phosphatidylinositol 3-kinase regulatory subunit alpha	Show » « Hide COSMIC Frameshift Mutations COSMIC Missense Mutations COSMIC Other Mutations COSMIC Somatic Mutations Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001953 [negative regulation of cell-matrix adhesion] GO:0003924 [GTPase activity] GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005942 [phosphatidylinositol 3-kinase complex] GO:0005943 [1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex] GO:0006468 [protein phosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030183 [B cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0031295 [T cell costimulation] GO:0034644 [cellular response to UV] GO:0035014 [phosphatidylinositol 3-kinase regulator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043125 [ErbB-3 class receptor binding] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0043559 [insulin binding] GO:0043560 [insulin receptor substrate binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050852 [T cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051531 [NFAT protein import into nucleus] GO:0060396 [growth hormone receptor signaling pathway] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]	732	84.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.