Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
|
TCF7L2-001 |
ENSP00000358402
ENST00000369395
|
Q5VVR7 Show all »
« Hide
Q5VVR7 [Target identity:100%; Query identity:100%]Transcription factor 7-like 2
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Show »
« Hide
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
|
317 |
34.9 |
No |
0 |
TCF7L2-002 |
ENSP00000345640
ENST00000346198
|
Q5VVR5 Show all »
« Hide
Q5VVR5 [Target identity:100%; Query identity:100%]Transcription factor 7-like 2
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Show »
« Hide
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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222 |
24.9 |
No |
0 |
TCF7L2-003 |
ENSP00000358404
ENST00000369397
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2 Q6FHW4 [Target identity:100%; Query identity:100%]TCF7L2 protein; Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_e C6ZRK5 [Target identity:97%; Query identity:100%]TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14; Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_i C6ZRK4 [Target identity:82%; Query identity:100%]TCF7L2 isoform pFC8A_TCF7L2_H2_ex3-11-12-13-14
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Show »
« Hide
COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001568 [blood vessel development] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007420 [brain development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0009749 [response to glucose stimulus] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0014003 [oligodendrocyte development] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0030282 [bone mineralization] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030538 [embryonic genitalia morphogenesis] GO:0031016 [pancreas development] GO:0031641 [regulation of myelination] GO:0032024 [positive regulation of insulin secretion] GO:0032092 [positive regulation of protein binding] GO:0032252 [secretory granule localization] GO:0032350 [regulation of hormone metabolic process] GO:0032993 [protein-DNA complex] GO:0035019 [somatic stem cell maintenance] GO:0035257 [nuclear hormone receptor binding] GO:0035411 [catenin import into nucleus] GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043570 [maintenance of DNA repeat elements] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0045295 [gamma-catenin binding] GO:0045444 [fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046621 [negative regulation of organ growth] GO:0046827 [positive regulation of protein export from nucleus] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048619 [embryonic hindgut morphogenesis] GO:0048625 [myoblast fate commitment] GO:0048641 [regulation of skeletal muscle tissue development] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048699 [generation of neurons] GO:0048713 [regulation of oligodendrocyte differentiation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060070 [canonical Wnt signaling pathway] GO:0060325 [face morphogenesis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070016 [armadillo repeat domain binding] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
|
596 |
65.3 |
No |
0 |
TCF7L2-004 |
ENSP00000298692
ENST00000349937
|
Q5VVR8 Show all »
« Hide
Q5VVR8 [Target identity:100%; Query identity:100%]Transcription factor 7-like 2
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Show »
« Hide
SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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288 |
31.5 |
No |
0 |
TCF7L2-006 |
ENSP00000358393
ENST00000369386
|
Q5JRY3 Show all »
« Hide
Q5JRY3 [Target identity:100%; Query identity:100%]Transcription factor 7-like 2 H0YEE5 [Target identity:90%; Query identity:100%]Transcription factor 7-like 2
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Show »
« Hide
COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
|
120 |
14.1 |
No |
0 |
TCF7L2-007 |
ENSP00000358396
ENST00000369389
|
Q5JRY4 Show all »
« Hide
Q5JRY4 [Target identity:100%; Query identity:100%]Transcription factor 7-like 2 B3KQC6 [Target identity:61%; Query identity:100%]cDNA FLJ90224 fis, clone NT2RM1000789, highly similar to Mus musculus transcription factor 7-like 2, T-cell specific, HMG-box (Tcf7l2), mRNA
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Show »
« Hide
COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
|
176 |
20.2 |
No |
0 |
TCF7L2-010 |
ENSP00000277945
ENST00000277945
|
Q5JRY5 Show all »
« Hide
Q5JRY5 [Target identity:100%; Query identity:100%]Transcription factor 7-like 2
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Show »
« Hide
COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
|
207 |
23.7 |
No |
0 |
TCF7L2-013 |
ENSP00000435694
ENST00000470254
|
H0YEE5 Show all »
« Hide
H0YEE5 [Target identity:100%; Query identity:100%]Transcription factor 7-like 2
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Show »
« Hide
COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
|
108 |
12.6 |
No |
0 |
TCF7L2-201 |
ENSP00000344823
ENST00000352065
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2 C6ZRJ9 [Target identity:99%; Query identity:100%]TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-11-13-13b B4E165 [Target identity:42%; Query identity:100%]cDNA FLJ59810, highly similar to Transcription factor 7-like 2
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Show »
« Hide
COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001568 [blood vessel development] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007420 [brain development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0009749 [response to glucose stimulus] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0014003 [oligodendrocyte development] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0030282 [bone mineralization] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030538 [embryonic genitalia morphogenesis] GO:0031016 [pancreas development] GO:0031641 [regulation of myelination] GO:0032024 [positive regulation of insulin secretion] GO:0032092 [positive regulation of protein binding] GO:0032252 [secretory granule localization] GO:0032350 [regulation of hormone metabolic process] GO:0032993 [protein-DNA complex] GO:0035019 [somatic stem cell maintenance] GO:0035257 [nuclear hormone receptor binding] GO:0035411 [catenin import into nucleus] GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043570 [maintenance of DNA repeat elements] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0045295 [gamma-catenin binding] GO:0045444 [fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046621 [negative regulation of organ growth] GO:0046827 [positive regulation of protein export from nucleus] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048619 [embryonic hindgut morphogenesis] GO:0048625 [myoblast fate commitment] GO:0048641 [regulation of skeletal muscle tissue development] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048699 [generation of neurons] GO:0048713 [regulation of oligodendrocyte differentiation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060070 [canonical Wnt signaling pathway] GO:0060325 [face morphogenesis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070016 [armadillo repeat domain binding] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
|
459 |
51.2 |
No |
0 |
TCF7L2-202 |
ENSP00000347949
ENST00000355717
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2 Q5JRY4 [Target identity:35%; Query identity:100%]Transcription factor 7-like 2 B3KQC6 [Target identity:22%; Query identity:100%]cDNA FLJ90224 fis, clone NT2RM1000789, highly similar to Mus musculus transcription factor 7-like 2, T-cell specific, HMG-box (Tcf7l2), mRNA
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Show »
« Hide
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
|
489 |
54.6 |
No |
0 |
TCF7L2-203 |
ENSP00000348274
ENST00000355995
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2 E2GH25 [Target identity:100%; Query identity:100%]T-cell factor-4 variant M; Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_j
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Show »
« Hide
SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001568 [blood vessel development] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007420 [brain development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0009749 [response to glucose stimulus] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0014003 [oligodendrocyte development] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0030282 [bone mineralization] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030538 [embryonic genitalia morphogenesis] GO:0031016 [pancreas development] GO:0031641 [regulation of myelination] GO:0032024 [positive regulation of insulin secretion] GO:0032092 [positive regulation of protein binding] GO:0032252 [secretory granule localization] GO:0032350 [regulation of hormone metabolic process] GO:0032993 [protein-DNA complex] GO:0035019 [somatic stem cell maintenance] GO:0035257 [nuclear hormone receptor binding] GO:0035411 [catenin import into nucleus] GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043570 [maintenance of DNA repeat elements] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0045295 [gamma-catenin binding] GO:0045444 [fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046621 [negative regulation of organ growth] GO:0046827 [positive regulation of protein export from nucleus] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048619 [embryonic hindgut morphogenesis] GO:0048625 [myoblast fate commitment] GO:0048641 [regulation of skeletal muscle tissue development] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048699 [generation of neurons] GO:0048713 [regulation of oligodendrocyte differentiation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060070 [canonical Wnt signaling pathway] GO:0060325 [face morphogenesis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070016 [armadillo repeat domain binding] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
|
619 |
67.9 |
No |
0 |
TCF7L2-204 |
ENSP00000443626
ENST00000534894
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2
|
Show »
« Hide
SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001568 [blood vessel development] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007420 [brain development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0009749 [response to glucose stimulus] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0014003 [oligodendrocyte development] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0030282 [bone mineralization] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030538 [embryonic genitalia morphogenesis] GO:0031016 [pancreas development] GO:0031641 [regulation of myelination] GO:0032024 [positive regulation of insulin secretion] GO:0032092 [positive regulation of protein binding] GO:0032252 [secretory granule localization] GO:0032350 [regulation of hormone metabolic process] GO:0032993 [protein-DNA complex] GO:0035019 [somatic stem cell maintenance] GO:0035257 [nuclear hormone receptor binding] GO:0035411 [catenin import into nucleus] GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043570 [maintenance of DNA repeat elements] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0045295 [gamma-catenin binding] GO:0045444 [fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046621 [negative regulation of organ growth] GO:0046827 [positive regulation of protein export from nucleus] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048619 [embryonic hindgut morphogenesis] GO:0048625 [myoblast fate commitment] GO:0048641 [regulation of skeletal muscle tissue development] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048699 [generation of neurons] GO:0048713 [regulation of oligodendrocyte differentiation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060070 [canonical Wnt signaling pathway] GO:0060325 [face morphogenesis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070016 [armadillo repeat domain binding] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
|
494 |
55.2 |
No |
0 |
TCF7L2-205 |
ENSP00000446238
ENST00000536810
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2 Q5JRY5 [Target identity:34%; Query identity:100%]Transcription factor 7-like 2
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Show »
« Hide
SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
602 |
66 |
No |
0 |
TCF7L2-206 |
ENSP00000446172
ENST00000538897
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Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2 B9X074 [Target identity:96%; Query identity:100%]T-cell factor-4 variant G; Transcription factor 7-like 2 isoform
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Show »
« Hide
SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001568 [blood vessel development] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007420 [brain development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0009749 [response to glucose stimulus] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0014003 [oligodendrocyte development] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0030282 [bone mineralization] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030538 [embryonic genitalia morphogenesis] GO:0031016 [pancreas development] GO:0031641 [regulation of myelination] GO:0032024 [positive regulation of insulin secretion] GO:0032092 [positive regulation of protein binding] GO:0032252 [secretory granule localization] GO:0032350 [regulation of hormone metabolic process] GO:0032993 [protein-DNA complex] GO:0035019 [somatic stem cell maintenance] GO:0035257 [nuclear hormone receptor binding] GO:0035411 [catenin import into nucleus] GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043570 [maintenance of DNA repeat elements] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0045295 [gamma-catenin binding] GO:0045444 [fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046621 [negative regulation of organ growth] GO:0046827 [positive regulation of protein export from nucleus] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048619 [embryonic hindgut morphogenesis] GO:0048625 [myoblast fate commitment] GO:0048641 [regulation of skeletal muscle tissue development] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048699 [generation of neurons] GO:0048713 [regulation of oligodendrocyte differentiation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060070 [canonical Wnt signaling pathway] GO:0060325 [face morphogenesis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070016 [armadillo repeat domain binding] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
|
482 |
53.7 |
No |
0 |
TCF7L2-207 |
ENSP00000443883
ENST00000542695
|
E2GH20 Show all »
« Hide
E2GH20 [Target identity:100%; Query identity:100%]T-cell factor-4 variant X2; Transcription factor 7-like 2
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Show »
« Hide
COSMIC Somatic Mutations COSMIC Translocations Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
335 |
36.9 |
No |
0 |
TCF7L2-208 |
ENSP00000444972
ENST00000543371
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2 E2GH26 [Target identity:100%; Query identity:99%]T-cell factor-4 variant L C6ZRJ8 [Target identity:96%; Query identity:100%]T-cell factor-4 variant J; TCF7L2 isoform pFC8A_TCF7L2_D4,ex1-11-13a-14
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Show »
« Hide
SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
|
602 |
66.1 |
No |
0 |
TCF7L2-209 |
ENSP00000440547
ENST00000545257
|
Q9NQB0 Show all »
« Hide
Q9NQB0 [Direct mapping]Transcription factor 7-like 2
|
Show »
« Hide
SCAMPI predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014)
|
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001568 [blood vessel development] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007420 [brain development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0009749 [response to glucose stimulus] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0014003 [oligodendrocyte development] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0030282 [bone mineralization] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030538 [embryonic genitalia morphogenesis] GO:0031016 [pancreas development] GO:0031641 [regulation of myelination] GO:0032024 [positive regulation of insulin secretion] GO:0032092 [positive regulation of protein binding] GO:0032252 [secretory granule localization] GO:0032350 [regulation of hormone metabolic process] GO:0032993 [protein-DNA complex] GO:0035019 [somatic stem cell maintenance] GO:0035257 [nuclear hormone receptor binding] GO:0035411 [catenin import into nucleus] GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043570 [maintenance of DNA repeat elements] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0045295 [gamma-catenin binding] GO:0045444 [fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046621 [negative regulation of organ growth] GO:0046827 [positive regulation of protein export from nucleus] GO:0048557 [embryonic digestive tract morphogenesis] GO:0048619 [embryonic hindgut morphogenesis] GO:0048625 [myoblast fate commitment] GO:0048641 [regulation of skeletal muscle tissue development] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048699 [generation of neurons] GO:0048713 [regulation of oligodendrocyte differentiation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060070 [canonical Wnt signaling pathway] GO:0060325 [face morphogenesis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070016 [armadillo repeat domain binding] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000675 [negative regulation of type B pancreatic cell apoptotic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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