CDH8

GENE INFORMATION

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Gene name

CDH8

Synonyms

Description

Cadherin 8, type 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q21

Chromosome location (bp)

61681146 - 62070939

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000150394 (version 75.37)

Entrez gene

1006

UniProt

P55286 (UniProt - Evidence at protein level)

neXtProt

NX_P55286

Antibodypedia

CDH8 antibodies
 

PROTEIN VIEW

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CDH8-001
 
CDH8-002
 
CDH8-003
 
CDH8-011
 
CDH8-012
 
CDH8-013
 
CDH8-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH8-001 ENSP00000462701
ENST00000577390
P55286
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Show » Show » 799 88.3 No 1
CDH8-002 ENSP00000462847
ENST00000584506
J3KT81
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Show » Show » 81 9.4 No 1
CDH8-003 ENSP00000463511
ENST00000584337
J3QLE6
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Show » Show » 532 58.9 No 0
CDH8-011 ENSP00000462976
ENST00000583382
J3KTG8
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Show » Show » 425 46.7 No 0
CDH8-012 ENSP00000462018
ENST00000577730
J3KRI5
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Show » Show » 744 82.7 No 1
CDH8-013 ENSP00000299345
ENST00000299345
J3KTG8
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Show » Show » 745 82.8 No 1
CDH8-014 ENSP00000463266
ENST00000585315
J3QKW5
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Show » Show » 476 52.5 No 0