CENPJ

GENE INFORMATION

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Gene name

CENPJ (HGNC Symbol)

Synonyms

BM032, CPAP, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4

Description

Centromere protein J (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

13

Cytoband

q12.12

Chromosome location (bp)

25457171 - 25497018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151849 (version 75.37)

Entrez gene

55835

UniProt

Q9HC77 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HC77

Antibodypedia

CENPJ antibodies
 

PROTEIN VIEW

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CENPJ-001
 
CENPJ-002
 
CENPJ-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CENPJ-001 ENSP00000371308
ENST00000381884
Q9HC77
Show all »
Show » Show » 1338 153 No 0
CENPJ-002 ENSP00000399334
ENST00000418179
Show » 196 23.5 No 0
CENPJ-201 ENSP00000441090
ENST00000545981
Q5JPD5
Show all »
Show » 1086 124.2 No 0