BAG3

GENE INFORMATION

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Gene name

BAG3

Synonyms

Description

BCL2-associated athanogene 3 (HGNC Symbol)

Entrez gene summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q26.11

Chromosome location (bp)

121410882 - 121437331

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151929 (version 75.37)

Entrez gene

9531

UniProt

O95817 (UniProt - Evidence at protein level)

neXtProt

NX_O95817

Antibodypedia

BAG3 antibodies
 

PROTEIN VIEW

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BAG3-001
 
BAG3-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAG3-001 ENSP00000358081
ENST00000369085
O95817
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Show » Show » 575 61.6 No 0
BAG3-002 ENSP00000410036
ENST00000450186
C9JFK9
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Show » Show » 325 34.8 No 0