ATP5A1 - Gene info - The Human Protein Atlas

ATP5A1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	ATP5A1 (HGNC Symbol)
Synonyms	ATP5A, ATP5AL2, ATPM, hATP1, OMR, ORM
Description	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	43664110 - 43684300
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152234 (version 75.37)
Entrez gene	498
UniProt	P25705 (UniProt - Evidence at protein level)
neXtProt	NX_P25705
Antibodypedia	ATP5A1 antibodies

PROTEIN VIEW

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ATP5A1-001		ATP5A1-002		ATP5A1-003		ATP5A1-004		ATP5A1-005		ATP5A1-008		ATP5A1-009		ATP5A1-014		ATP5A1-016		ATP5A1-018		ATP5A1-020		ATP5A1-021		ATP5A1-201		ATP5A1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5A1-001	ENSP00000381736 ENST00000398752	P25705 Show all » « Hide P25705 [Direct mapping] ATP synthase subunit alpha, mitochondrial K7EK77 [Target identity:37%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7ERX7 [Target identity:37%; Query identity:100%] ATP synthase subunit alpha, mitochondrial B4DGW3 [Target identity:30%; Query identity:100%] cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial K7EJP1 [Target identity:26%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7EQH4 [Target identity:20%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Plasma proteins Mitochondrial proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0006200 [ATP catabolic process] GO:0006629 [lipid metabolic process] GO:0006754 [ATP biosynthetic process] GO:0008180 [COP9 signalosome] GO:0009790 [embryo development] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0042288 [MHC class I protein binding] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism]	553	59.7	No	0
ATP5A1-002	ENSP00000466309 ENST00000590156	K7EM08 Show all » « Hide K7EM08 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		58	6.4	No	0
ATP5A1-003	ENSP00000465497 ENST00000589869	K7EK77 Show all » « Hide K7EK77 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial B4DGW3 [Target identity:80%; Query identity:100%] cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial K7EJP1 [Target identity:70%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7EQH4 [Target identity:53%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0006629 [lipid metabolic process] GO:0009790 [embryo development] GO:0015992 [proton transport] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]	207	22.2	No	0
ATP5A1-004	ENSP00000465259 ENST00000590324	K7EJP1 Show all » « Hide K7EJP1 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7EQH4 [Target identity:76%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0006629 [lipid metabolic process] GO:0009790 [embryo development] GO:0015992 [proton transport] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]	145	15.3	No	0
ATP5A1-005	ENSP00000468458 ENST00000590406	K7ERX7 Show all » « Hide K7ERX7 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7EJP1 [Target identity:70%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7EQH4 [Target identity:54%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0006629 [lipid metabolic process] GO:0009790 [embryo development] GO:0015992 [proton transport] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]	205	21.6	No	0
ATP5A1-008	ENSP00000466275 ENST00000586592		Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		90	9.2	No	0
ATP5A1-009	ENSP00000467037 ENST00000590665	K7ENP3 Show all » « Hide K7ENP3 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005524 [ATP binding] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism]	531	57.5	No	0
ATP5A1-014	ENSP00000467983 ENST00000585650	K7EQU6 Show all » « Hide K7EQU6 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		78	9.4	Yes	0
ATP5A1-016	ENSP00000467830 ENST00000592989	K7EQH4 Show all » « Hide K7EQH4 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0006629 [lipid metabolic process] GO:0009790 [embryo development] GO:0015992 [proton transport] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]	111	11.7	No	0
ATP5A1-018	ENSP00000466975 ENST00000589252	K7ENJ4 Show all » « Hide K7ENJ4 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005524 [ATP binding]	199	21.3	No	0
ATP5A1-020	ENSP00000465805 ENST00000591981	K7EKV9 Show all » « Hide K7EKV9 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		44	4.8	No	0
ATP5A1-021	ENSP00000468618 ENST00000592364	K7ESA0 Show all » « Hide K7ESA0 [Target identity:100%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		77	8.3	No	0
ATP5A1-201	ENSP00000282050 ENST00000282050	P25705 Show all » « Hide P25705 [Direct mapping] ATP synthase subunit alpha, mitochondrial K7EK77 [Target identity:37%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7ERX7 [Target identity:37%; Query identity:100%] ATP synthase subunit alpha, mitochondrial B4DGW3 [Target identity:30%; Query identity:100%] cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial K7EJP1 [Target identity:26%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7EQH4 [Target identity:20%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Plasma proteins Mitochondrial proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0006200 [ATP catabolic process] GO:0006629 [lipid metabolic process] GO:0006754 [ATP biosynthetic process] GO:0008180 [COP9 signalosome] GO:0009790 [embryo development] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0042288 [MHC class I protein binding] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism]	553	59.7	No	0
ATP5A1-202	ENSP00000465477 ENST00000593152	P25705 Show all » « Hide P25705 [Direct mapping] ATP synthase subunit alpha, mitochondrial K7EK77 [Target identity:41%; Query identity:100%] ATP synthase subunit alpha, mitochondrial B4DGW3 [Target identity:33%; Query identity:100%] cDNA FLJ54625, highly similar to ATP synthase subunit alpha, mitochondrial K7EJP1 [Target identity:28%; Query identity:100%] ATP synthase subunit alpha, mitochondrial K7EQH4 [Target identity:22%; Query identity:100%] ATP synthase subunit alpha, mitochondrial	Show » « Hide Plasma proteins Mitochondrial proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001937 [negative regulation of endothelial cell proliferation] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0006200 [ATP catabolic process] GO:0006629 [lipid metabolic process] GO:0006754 [ATP biosynthetic process] GO:0008180 [COP9 signalosome] GO:0009790 [embryo development] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0042288 [MHC class I protein binding] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)] GO:0046034 [ATP metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism]	503	54.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.