DKK2

GENE INFORMATION

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Gene name

DKK2

Synonyms

Description

Dickkopf WNT signaling pathway inhibitor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

107842959 - 108204963

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000155011 (version 75.37)

Entrez gene

27123

UniProt

Q9UBU2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBU2

Antibodypedia

DKK2 antibodies
 

PROTEIN VIEW

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DKK2-001
 
DKK2-003
 
DKK2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DKK2-001 ENSP00000285311
ENST00000285311
Q9UBU2
Show all »
Show » Show » 259 28.4 Yes 0
DKK2-003 ENSP00000421255
ENST00000513208
D6RGF1
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Show » Show » 159 18.1 No 0
DKK2-004 ENSP00000423797
ENST00000510463
D6RCC2
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Show » Show » 213 24 No 0