AZIN1

GENE INFORMATION

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Gene name

AZIN1 (HGNC Symbol)

Synonyms

OAZI, OAZIN, ODC1L

Description

Antizyme inhibitor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

Chromosome

8

Cytoband

q22.3

Chromosome location (bp)

103838585 - 103906092

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000155096 (version 75.37)

Entrez gene

51582

UniProt

O14977 (UniProt - Evidence at transcript level)

neXtProt

NX_O14977

Antibodypedia

AZIN1 antibodies
 

PROTEIN VIEW

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AZIN1-001
 
AZIN1-002
 
AZIN1-006
 
AZIN1-007
 
AZIN1-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AZIN1-001 ENSP00000337180
ENST00000337198
O14977
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Show » 448 49.5 No 0
AZIN1-002 ENSP00000321507
ENST00000347770
O14977
Show all »
Show » 448 49.5 No 0
AZIN1-006 ENSP00000475919
ENST00000521536
U3KQI8
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Show » 165 18.2 No 0
AZIN1-007 ENSP00000429215
ENST00000518353
E5RJ16
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Show » 33 3.7 No 0
AZIN1-013 ENSP00000429449
ENST00000520402
E5RIB7
Show all »
Show » 97 10.5 No 0