F11R

GENE INFORMATION

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Gene name

F11R (HGNC Symbol)

Synonyms

CD321, JAM-1, JAM-A, JAM1, JAMA, JCAM, PAM-1

Description

F11 receptor (HGNC Symbol)

Entrez gene summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

160965001 - 160991138

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158769 (version 75.37)

Entrez gene

50848

UniProt

Q9Y624 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y624

Antibodypedia

F11R antibodies
 

PROTEIN VIEW

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F11R-001
 
F11R-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F11R-001 ENSP00000357005
ENST00000368026
Q9Y624
Show all »
Show » Show » 299 32.6 Yes 1
F11R-002 ENSP00000440812
ENST00000537746
B7Z941
Show all »
Show » Show » 250 27.2 Yes 1