RYK

GENE INFORMATION

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Gene name

RYK (HGNC Symbol)

Synonyms

D3S3195, JTK5, JTK5A, RYK1

Description

Receptor-like tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Chromosome

3

Cytoband

q22.2

Chromosome location (bp)

133784147 - 133969689

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163785 (version 75.37)

Entrez gene

6259

UniProt

P34925 (UniProt - Evidence at protein level)

neXtProt

NX_P34925

Antibodypedia

RYK antibodies
 

PROTEIN VIEW

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RYK-001
 
RYK-004
 
RYK-007
 
RYK-201
 
RYK-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RYK-001 ENSP00000419122
ENST00000460933
Show » Show » 587 65.7 Yes 1
RYK-004 ENSP00000417836
ENST00000486725
Show » Show » 93 10.8 No 0
RYK-007 ENSP00000475203
ENST00000472234
U3KPT6
Show all »
Show » Show » 157 17.6 No 0
RYK-201 ENSP00000296084
ENST00000296084
P34925
Show all »
Show » Show » 608 67.9 Yes 1
RYK-202 ENSP00000399527
ENST00000427044
F5H8L5
Show all »
Show » Show » 418 47.1 No 1