HHIP

GENE INFORMATION

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Gene name

HHIP (HGNC Symbol)

Synonyms

FLJ20992, HIP

Description

Hedgehog interacting protein (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]

Chromosome

4

Cytoband

q31.21

Chromosome location (bp)

145567173 - 145666423

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164161 (version 75.37)

Entrez gene

64399

UniProt

Q96QV1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96QV1

Antibodypedia

HHIP antibodies
 

PROTEIN VIEW

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HHIP-001
 
HHIP-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HHIP-001 ENSP00000296575
ENST00000296575
Q96QV1
Show all »
Show » Show » 700 78.9 Yes 0
HHIP-002 ENSP00000408587
ENST00000434550
Q96QV1
Show all »
Show » Show » 320 36.4 Yes 1